Accelerating TMS for Cervical Dystonia

The primary aim of this research is to investigate the impact of transcranial magnetic stimulation (TMS) on both brain function and behavioral outcomes among individuals with cervical dystonia. A previous TMS study carried out by our team revealed that the application of TMS using a personalized brain targeting approach in focal hand dystonia resulted in improved measures of writing disfluency and changes in the motor network. This study seeks to expand these promising findings to individuals with cervical dystonia. Subjects in the study will receive four TMS sessions in a single day with a protocol referred to as "accelerated TMS." The investigation will consist of a total of 8 in-person appointments. Participants with cervical dystonia will receive accelerated TMS during two in-person visits. Following each TMS session, participants will evaluate changes in brain function using function MRI and behavior using a behavior assay. The principal risk associated with TMS is the possibility of inducing a seizure. However, this study will strictly adhere to safety guidelines, utilizing TMS levels that have not previously been linked to seizures in properly screened individuals. The dosages of TMS proposed for use in this study have not caused seizures in healthy volunteers. To further mitigate the risk of seizures, potential subjects will undergo medical screening for any known factors that could predispose them to seizures. The primary advantage of this study is that it may improve neck movement behavior in patients with cervical dystonia, while also advancing our understanding in brain function before and after TMS intervention. The discoveries stemming from this investigation will pave the way for future research endeavors aimed at advancing brain stimulation as a viable clinical therapy for cervical dystonia.

Inclusion criteria

for cervical dystonia subjects:

• 18yrs and older
• Diagnosed with isolated cervical dystonia by Neurologist
• Must be able to sign an informed consent
• Must be literate

Exclusion criteria

for cervical dystonia subjects:

• Other neurological movement disorders diagnoses including other types of dystonia, Parkinsonism, or essential tremor
• History of seizure disorder
• Concomitant medications known to decrease seizure threshold
• Illicit drug use
• No TMS therapy for another indication within one month of this research study
• Botulinum toxin injections within 3 months of the research study
• Medications used for symptom treatment of dystonia including anticholinergic, benzodiazepines, and muscle relaxants among others within one month of the study
• No physical or occupational therapy of the neck within one month of the study
• Any contraindications to MRI or TMS

Inclusion criteria

for cervical dystonia subjects considering DBS

• 18yrs and older
• diagnosed with cervical dystonia by a Neurologist
• must be able to sign informed consent
• must be literate
• On no medications or one medication to treat symptoms of dystonia for a minimum of one month prior to study participation

Exclusion criteria

for cervical dystonia subjects considering DBS

• other neurological movement disorders diagnoses including Parkinsonism, or essential tremor
• botulinum toxin injections within 3 months of research study
• More than two medications used for symptom treatment of dystonia including anticholinergic, benzodiazepines, and muscle relaxants among others within one month of the study
• contraindications to MRI or TMS
• a history of seizures and anti-seizure medications by review of medical records