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Completed

NCT Number: NCT04427527

Accelerating Colorectal Cancer Screening Through Implementation Science in Appalachia

This project aims to implement a multi-level group randomized trial, delayed intervention that includes components targeting clinics, providers, patients, and the community to increase colorectal cancer (CRC) screening, follow-up, and referral-to-care among patients age 50-74 in 12 counties in Appalachian Kentucky and Ohio. The 12 counties will be assigned to one of two study groups (early vs. delayed) and outcome measures (rate of CRC screening) will be obtained from clinic-level electronic health record data and a county-level behavioral assessment telephone survey. The hypothesis for the project is that the multi-level intervention will increase the clinic and county level CRC screening rates.

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Key information

Conditions

Colorectal Cancer Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Rectal Diseases

Age range

50 year–74 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Markey Cancer Center, Lexington, Kentucky, United States

Loading trial locations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age 50-74
  • all races, sexes and genders
  • resident of the study area

Exclusion criteria

.no exclusions based on gender, race or ethnicity

Treatment and study plan

Multi-level intervention to increase CRC screening

Behavioral

Intervention for the community, providers, patients, clinics and systems

Primary outcomes

  1. CRC screening - clinic level

    Time frame: 12 months

    Change in clinic-level screening rate from baseline to the end of the 12-month active intervention period, assessed through clinic electronic health record data

Secondary outcomes

  1. CRC screening - community level

    Time frame: 12 months

    Self-reported participation in CRC screening from baseline to the end of the 12-month active intervention period, assessed through telephone surveys

Sponsors and collaborators

Lead sponsor

University of Kentucky

Other

Collaborators

  • National Cancer Institute (NCI)
  • Ohio State University

Registry information

Official study title

Accelerating Colorectal Cancer Screening Through Implementation Science in Appalachia (ACCSIS)

Acronym: ACCSIS

Important dates

Study start
2020
Primary completion
2025
Study completion
2025
First posted
Jun 11, 2020
Registry last updated
Oct 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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