Riphah International University
Lahore, Punjab Province, 55000, Pakistan
Location status: Recruiting
Location contact
Humera Ayub, MSCPPT
PRINCIPAL_INVESTIGATOR
Tanzeela Nazir, MSCPPT
CONTACT
Tanzeela Nazir, MSCPPT
PRINCIPAL_INVESTIGATOR
NCT Number: NCT07737093
Lobectomy patients frequently experience postoperative respiratory complications such as secretion retention, dyspnea, impaired gas exchange, and reduced lung function, which can delay recovery. Oscillatory Positive Expiratory Pressure (OPEP) devices such as Acapella and Flutter are commonly used to improve airway clearance and pulmonary function. This study aims to compare the effects of Acapella and Flutter devices on secretion clearance, dyspnea, arterial blood gases, and lung function in post-lobectomy patients.
Interested in participating?
Request Info35 year–54 year
All sexes
Interventional
Not applicable
Lahore, Punjab Province, 55000, Pakistan
Location status: Recruiting
Humera Ayub, MSCPPT
PRINCIPAL_INVESTIGATOR
Tanzeela Nazir, MSCPPT
CONTACT
Tanzeela Nazir, MSCPPT
PRINCIPAL_INVESTIGATOR
Lobectomy is a common surgical procedure performed for the treatment of various pulmonary conditions, particularly lung cancer. Although effective, the procedure is often associated with postoperative respiratory complications including mucus retention, reduced lung volumes, impaired ventilation, and difficulty breathing. These complications can prolong hospital stay, increase the risk of infection, and negatively affect functional recovery.
Respiratory physiotherapy plays an important role in preventing and managing these complications. Oscillatory Positive Expiratory Pressure (OPEP) devices are widely used to facilitate airway clearance by generating positive expiratory pressure and oscillations during exhalation. These mechanisms help mobilize retained secretions, improve ventilation, enhance lung expansion, and support overall pulmonary recovery.
Acapella and Flutter are two commonly used OPEP devices. Both have demonstrated beneficial effects on mucus clearance, pulmonary function, oxygenation, and symptom management in patients with respiratory disorders and postoperative conditions. Previous studies have reported improvements in respiratory parameters and functional outcomes following the use of these devices as part of pulmonary rehabilitation programs.
Despite the growing use of OPEP devices in clinical practice, evidence directly comparing Acapella and Flutter in patients recovering from lobectomy remains limited. Most available studies have focused on chronic respiratory diseases or evaluated these devices independently rather than comparing their effectiveness in a postoperative population. Furthermore, limited information is available regarding their relative effects on secretion clearance, dyspnea, arterial blood gases, and lung function after lobectomy. Therefore, this study is designed to address this gap and provide evidence regarding the comparative effectiveness of Acapella and Flutter devices in postoperative pulmonary rehabilitation.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Flutter Device Therapy (Experimental Arm 2):
Participants will use the Flutter device, which generates oscillating positive expiratory pressure during exhalation to mobilize bronchial secretions. Patients will be instructed in correct positioning and breathing technique. The intervention will also be administered twice daily for 7 days using a standardized protocol.
Time frame: Postoperative Day 1, Postoperative Day 3, and Postoperative Day 5
Change in perceived breathlessness measured using the Modified Borg Dyspnea Scale (0-10, higher scores indicate greater dyspnea).
Time frame: Postoperative Day 1, Postoperative Day 3, and Postoperative Day 5
Forced Expiratory Volume in one second (FEV₁) measured using spirometry and reported in liters (L).
Time frame: Postoperative Day 1, Postoperative Day 3, and Postoperative Day 5
Forced Vital Capacity (FVC) measured using spirometry and reported in liters (L).
Time frame: Postoperative Day 1, Postoperative Day 3, and Postoperative Day 5
Ratio of Forced Expiratory Volume in one second to Forced Vital Capacity (FEV₁/FVC) measured using spirometry and reported as a percentage (%).
Time frame: Postoperative Day 1, Postoperative Day 3, and Postoperative Day 5
Volume of sputum expectorated over a 24-hour period, reported in milliliters (mL), to assess airway secretion clearance.
Time frame: Postoperative Day 1, Postoperative Day 3, and Postoperative Day 5
Arterial partial pressure of oxygen (PaO₂) measured using arterial blood gas analysis and reported in millimeters of mercury (mmHg).
Time frame: Postoperative Day 1, Postoperative Day 3, and Postoperative Day 5
Arterial partial pressure of carbon dioxide (PaCO₂) measured using arterial blood gas analysis and reported in millimeters of mercury (mmHg).
Time frame: Postoperative Day 1, Postoperative Day 3, and Postoperative Day 5
Arterial blood pH measured using arterial blood gas analysis.
Time frame: Postoperative Day 1, Postoperative Day 3, and Postoperative Day 5
Arterial bicarbonate (HCO₃-) concentration measured using arterial blood gas analysis and reported in millimoles per liter (mmol/L).
Time frame: Postoperative Day 1 and Postoperative Day 5
Number of participants with radiographic evidence of postoperative atelectasis as assessed by standard chest radiography.
Time frame: Postoperative Day 1 and Postoperative Day 5
Number of participants with radiographic evidence of pleural effusion as assessed by standard chest radiography.
Contact information is provided by the study sponsor or research team.
Riphah International University
Other
Comparative Effects of Acapella and Flutter Devices on Secretion Clearance, Dyspnea, Arterial Blood Gases, and Lung Function Test in Post-Lobectomy Patients
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