Abscisic Acid Effects on Glucose Homeostasis and Insulin Sensitivity

Inclusion criteria

• Provision of signed and dated informed consent form
• Stated willingness to comply with all study procedures and availability for the duration of the study
• Male or female, aged 18-65
• In good general health as evidenced by medical history or diagnosed with <specify condition/disease> or exhibiting <specify clinical signs or symptoms or physical/oral examination findings>
• Fasting glucose >5.6 and<7.0 mmol/L and/or HbA1C >5.6 and <6.5 %
• Ability to take oral medication and be willing to adhere to the <study intervention> regimen
• Females currently on hormone replacement therapy (HRT) can participate in the study if they have been on HRT for at least 6 months and will continue to be on HRT during the study.
• For males of reproductive potential: use of condoms or other methods to ensure effective contraception with partner
• Agreement to adhere to Lifestyle Considerations throughout study duration.

Exclusion criteria

• Treated or untreated diabetes
• 19>BMI<40.0 kg/m2
• Blood pressure (BP) ≤ 150mmHg systolic and ≤ 95 mmHg diastolic
• Current use of medications or antioxidant vitamins or supplements that would impact dependent variables, including glucose metabolism.
• Past or current ischemic heart disease, stroke, respiratory disease, endocrine or metabolic disease, neurological disease, hematological-oncological disease and free of recent infection (prior 2 weeks)
• Pregnancy or lactation
• Treatment with another investigational drug or other intervention within 1 year.
• Current smoker or tobacco use within the past year.
• Disqualifying findings on physical examination include cardiac murmurs, diminished pulses or the presence of bruits in the lower extremities, lower extremity thrombophlebitis, evidence of peripheral neuropathy, paresis or edema.