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NCT Number: NCT06735066

Abnormalities of Preoperative Ascending Urethrocystography and Outcomes of Living Donor Kidney Transplantation

To evaluate effects of abnormalities in preoperative ascending urethrocystography on the short-term outcomes of LDKT

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Key information

Age range

5 year–80 year

Sex eligibility

All sexes

Study type

Observational

About this study

The incidence of surgical complications after kidney transplantation (KT) has decreased in recent decades due to improvements in surgical techniques and immunosuppression protocols. However, the preoperative abnormalities of the urinary tract may influence the outcomes of KT. Hence, the preoperative evaluation of the urinary tract is a critical step in the KT process to identify the potential risk factors for poor outcomes .

Ascending urethrocystography (AUC) is a key diagnostic tool to assess the integrity and functionality of the lower urinary tract . It provides detailed insights into the bladder, urethra, vesicoureteral valves, and surrounding structures, identifying any abnormalities that could pose risks during or after KT . Understanding this issue is crucial, as certain urological anomalies may predispose patients to complications such as urinary leaks, infections, or delayed graft function, potentially leading to poorer short-term outcomes .

Although AUC is used indiscriminately as a screening test for urological abnormalities, only 6% of all KT recipients may have abnormal lower urinary tract . Few studies have looked at the yield from AUC and attempted to assess objectively whether certain patients could be selected for KT based on a positive result in AUC . Accordingly, the impact of abnormalities detected in AUC on the short-term outcomes of living donor KT (LDKT) remains inefficiently studied .

This is the rationale to conduct this cohort study on patients undergoing LDKT. We hypothesize that the presence of abnormalities in AUC will influence the surgical outcomes and short-term survival rates after LDKT

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pediatric and adult patients undergoing LDKT in Assiut Kidney Transplantation Unit.
  • Patients with preoperative evaluation by AUC.

Exclusion criteria

  • Patients with a primary non-functioning graft after LDKT.
  • Patients with missing relevant preoperative or postoperative data.
  • Patients refusal to participate in the study.

Treatment and study plan

Ascending urethrocystography

Procedure

It will be performed after instructing the patient to evacuate the bladder. A contrast agent will be infused through the urethra under fluoroscopy, using a urethral catheter or Knutson's clamp at the external urethral meatus. When the bladder is full, an anteroposterior film and two oblique films will be taken. Voiding cystourethrography will be performed as a part of this imaging examination. From this procedure, the following findings may be diagnosed:

  • Upper urinary tract: Vesicoureteral reflux (VUR); laterality and degrees of VUR will be defined.
  • Bladder: Capacity (defunctionalized, Small-sized or contracted bladder), neurogenic bladder, bladder diverticulum, filling defects, etc.
  • Urethra: Stricture and filling defects.

Primary outcomes

  1. The incidence of urinary complications post kidney transplantation

    Time frame: 6 month

    Each patient will be followed up for the surgical complications for 6- month duration after KT

Study contacts

Contact information is provided by the study sponsor or research team.

Shehabeldin Saad

CONTACT

[email protected]

+201067076462

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Effects of Abnormalities of Preoperative Ascending Urethrocystography on the Short-term Outcomes of Living Donor Kidney Transplantation

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Dec 16, 2024
Registry last updated
Dec 16, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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