Abdominal Ultrasound With Doppler and Peripheral Hemogram in Assesment Inflammatory Bowel Disease

assessment of inflammatory bowel disease patients in activity and remission by abdominal ultrasound examine non-invasive and in physiological condition by measuring the colon wall thickness in diagnosis and follow up the patient also including extra intestinal features such as the splanchnic vessels,mesentery and lymph nodes . Doppler u.s can evaluate bowel wall vascularity In activity and remission . peripheral hemogram in relationship to activity inflammatory bowel disease asses anemia ,increase monocyte and decrease mean platelet volume( MPV) . also,the investigator will evaluate the outcome of different lines of treatment traditional and biologic therapy (response to treatment,times of activity and complications)

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Key information

Conditions

Inflammatory Bowel Diseases Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Intestinal Diseases

Age range

15 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hyam Fathy

Asyut, Egypt

About this study

the participants will follow up the patient for 1 year in the first visit

All patients in this study will be subjected to:

Detailed history.
Careful physical examination
laboratory investigation

complete blood picture.
liver function
kidney function
Iron profile(serum iron ,serum ferritin
ESR (erythrocyte sedimentation rate )

g-CRP (C reactive protein) f-LDH (lactate dehydrogenase)

Abdominal us(the colon wall thickness,lymph nodes,mass,other organs)
Doppler us (mesenteric vessels)
colonoscopy after 1 year of treatment follow up every 3 months by abdominal US and peripheral hemogram and last visit after 1 year colonoscopy and biopsy for assessment response to treatment

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients diagnosed ulcerative colitis at age(15-60)
patients diagnosed crohns disease at age(15-60)k

Exclusion criteria

liver cirrhosis and portal hypertension
spontaneous bacterial peritonitis
Ischemic colitis

Treatment and study plan

Infliximab

Drug

follow up the patients who received this drugs for 1 year by abdominal ultrasound,peripheral hemogram and colonoscopy

Other names: steroid,immuran 5ASA

Primary outcomes

the role abdominal ultrasound in assessment inflammatory bowel disease

Time frame: 2 year

measure the thickness of the colon by abdominal ultrasound and doppler mesenteric vessels .more than 4ml detect activity doppler mesenteric highly vascularity in activity

Other outcomes

Assesment inflammatory bowel disease by complete blood picture

Time frame: 2year

follow up haemoglobin level (less than 10 mg) indicate anemia which mean the patient uncontrolled monocyte( monocyte more than 12% of white blood cell count detect activity) Mean platelet volume less than 6 fl which decrease in activity inflammatory bowel disease

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Important dates

Study start: 2018
Primary completion: 2021
Study completion: 2021
First posted: Feb 26, 2018
Registry last updated: Aug 29, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed