AB-1005 Long-Term Follow-up Study

This is an observational, long term, follow-up study for participants with Parkinson's disease (PD) or Multiple System Atrophy-Parkinsonian subtype (MSA-P) who participated in prior interventional studies with AB-1005. It is intended to better understand the long-term safety of AB-1005, how well tolerated it is and how long lasting the effects are.

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Key information

Conditions

Parkinson's Disease Autonomic Nervous System Diseases Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Multiple System Atrophy Multiple System Atrophy, Parkinson Variant Nervous System Diseases Neurodegenerative Diseases Parkinson Disease Parkinsonian Disorders Primary Dysautonomias Synucleinopathies

Sex eligibility

All sexes

Study type

Observational

Primary location

University of California San Francisco, San Francisco, California, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

PD and MSA-P participants that are or were enrolled in an interventional AB-1005 study and provide informed consent

Exclusion criteria

There are no exclusion criteria

Treatment and study plan

observation

Other

This is an observational study in which safety laboratories and non-invasive routine clinical assessments are conducted to gauge long term safety and efficacy.

Primary outcomes

Long term safety and tolerability

Time frame: Up to 10 years post surgery

Measure of the occurrence of serious and non-serious adverse events

Sponsors and collaborators

Lead sponsor

AskBio Inc

Industry

Registry information

Official study title

Long-Term Safety and Efficacy Follow-up of AB-1005 Gene Transfer Study Participants With Parkinson's Disease or Multiple System Atrophy

Important dates

Study start: 2025
Primary completion: 2037
Study completion: 2038
First posted: Jul 23, 2025
Registry last updated: Oct 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed