A Trial to Learn How Well REGN9933 Works for Preventing Blood Clots After Knee Replacement Surgery in Adult Participants

Key Inclusion Criteria:

• Undergoing elective unilateral TKA
• Has a body weight ≤130 kg at screening visit
• Is judged by the investigator to be in good health based on medical history, physical examination, vital sign measurements, and Electrocardiograms (ECG) performed at screening and/or prior to administration of initial dose of study drug
• Is in good health based on laboratory safety testing obtained during the screening period as described in the protocol

Key Exclusion Criteria:

• History of bleeding in the past 6 months requiring hospitalization or transfusion; history of intracranial or intraocular bleeding, excessive operative or post-operative bleeding, and traumatic spinal or epidural anesthesia; history of bleeding diathesis.
• History of thromboembolic disease or thrombophilia
• History of major surgery, including brain, spinal, or ocular, within approximately the past 6 months.
• History of major trauma within approximately the past 6 months.
• Hospitalized (>24 hours) for any reason within 30 days of the screening visit
• Using the Modification of Diet in Renal Disease equation, has an estimated glomerular filtration rate as described in the protocol

Note: Other protocol-defined Inclusion/ Exclusion Criteria apply