A Trial to Learn How Well REGN7508 Works for Preventing Blood Clots After a Knee Replacement in Adult Participants

Key Inclusion Criteria:

• Undergoing a primary elective unilateral TKA
• Has a body weight ≤130 kg at screening visit
• Is judged by the investigator to be in good health based on medical history, physical examination, vital sign measurements, and electrocardiograms (ECG's) performed at screening and/or prior to administration of initial dose of study drug as described in the protocol
• Is in good health based on laboratory safety testing obtained during the screening period as described in the protocol

Key Exclusion Criteria:

• History of bleeding in the past 6 months prior to dosing requiring hospitalization or transfusion; history of intracranial or intraocular bleeding, excessive operative or post-operative bleeding, and traumatic spinal or epidural anesthesia; history of bleeding diathesis
• History of thromboembolic disease or thrombophilia
• History of major surgery, including brain, spinal, or ocular, within approximately the past 6 months
• History of major trauma within approximately the past 6 months prior to dosing
• Hospitalized (>24 hours) for any reason within 30 days of the screening visit
• Has an estimated glomerular filtration rate (GFR) of <45 mL/min/1.73m^2 at the screening visit using one of the following formulas: the Modification of Diet in Renal Disease (MDRD) equation, the Chronic Kidney Disease Epidemiology Collaboration equation, or equivalent equation

Note: Other protocol-defined Inclusion/ Exclusion Criteria apply