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Completed

NCT Number: NCT04727021

A Trial to Learn How Much Rivaroxaban Gets Into the Blood When Taken in Different Forms and How Safe They Are in Healthy Men

Researchers are looking for a better way to treat venous thromboembolic disease, also known as VTE. In people with VTE, blood clots form in the veins of the legs, groin, or arms. These clots or a piece of a clot can break free and move around the body in the blood vessels. These clots can block small blood vessels, causing other conditions like high blood pressure, heart attack, and stroke.

Before people with a medical condition can take an approved treatment in a new form, researchers do trials in healthy participants. This helps them understand how the new form acts in the body and to better understand its safety.

In this trial, the researchers will compare how much of the trial treatment gets into the blood when taken in 2 different forms in a small number of participants. The trial will include about 30 men who are aged 18 to 55.

In this trial, there will be 2 groups of participants. The participants will take rivaroxaban in the current tablet form and in a new liquid form 1 time. This was a "crossover" trial. In a crossover trial, all the participants will take both forms of the treatments, but in a different order.

During the trial, the participants will stay at their trial site 2 times for 5 days. But, the participants can be in the trial for up to about 6 weeks. During the trial, the doctors will take blood and urine samples and check the participants' heart health using an electrocardiogram (ECG) and measure the blood pressure. The participants will also answer questions about how they are feeling, if they have any medical problems, and about any medications they are taking.

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Key information

Conditions

Healthy Volunteers

Age range

18 year–55 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 1

Primary location

CRS Clinical-Research-Services Mönchengladbach GmbH

Mönchengladbach, North Rhine-Westphalia, 41061, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy male subjects.
  • Age: 18 to 55 years (inclusive) at the screening examination/visit.
  • Race: White (Note: Clinical Data Interchange Standards Consortium definition of White: Denotes a person with European, Middle Eastern, or North African ancestral origin who identifies, or is identified, as White (Food and Drug Administration [FDA]).
  • Body mass index (BMI): above/equal 18 and below/equal 29.9 kg/m2.
  • Ability to understand and follow instructions.

Exclusion criteria

  • Pre-existing diseases for which it can be assumed that the absorption, distribution, metabolism, elimination and effects of the study drugs will not be normal
  • Known or suspected liver disorders and bile secretion/flow
  • Subjects with thyroid disorders as evidenced by assessment of thyroid stimulating hormone (TSH) levels outside the normal reference range at screening
  • Personal or familial history of genetically muscular diseases
  • Known hypersensitivity to the study drugs (active substances or excipients of the preparations)
  • Known severe allergies e.g. allergies to more than 3 allergens, allergies affecting the lower respiratory tract- allergic asthma, allergies requiring therapy with corticosteroids, urticaria) or significant non-allergic drug reactions
  • Known disorders with increased bleeding risk (e.g., periodontosis, hemorrhoids, acute gastritis, peptic ulcer)
  • Known sensitivity to common causes of bleeding (e.g. nasal)
  • Clinically relevant findings in the electrocardiogram (ECG) such as a second- or third-degree atrioventricular (AV) block, prolongation of the QRS (QRS interval in ECG) complex over 120 msec or of the QTc-interval over 450 msec at the first screening visit
  • Presence or history of arrhythmic disturbances; or known congenital QT (QT interval in ECG) prolongation
  • Systolic blood pressure below 100 or above 140 mmHg
  • Diastolic blood pressure below 50 or above 90 mmHg
  • Heart rate below 50 or above 90 beats/ min

Treatment and study plan

20 mg tablet rivaroxaban

Drug

Single oral dose of a 20 mg tablet rivaroxaban, administered under fed conditions

20 mg rivaroxaban, granules for oral suspension

Drug

Single oral dose of 20 mg rivaroxaban, granules for oral suspension administered under fed conditions.

Primary outcomes

  1. AUC of rivaroxaban granules for oral suspension vs. rivaroxaban tablet

    Time frame: From pre-dose up to 72 hours after drug administration

    AUC = area under the concentration vs. time curve from zero to infinity after single (first) dose

    Rivaroxaban Blood sampling for rivaroxaban pharmacokinetics in plasma.

  2. AUC(0-tlast) of rivaroxaban granules for oral suspension vs. rivaroxaban tablet

    Time frame: From pre-dose up to 72 hours after drug administration

    AUC(0-tlast) = AUC from time 0 to the last data point > lower limit of quantification (LLOQ)

    Rivaroxaban Blood sampling for rivaroxaban pharmacokinetics in plasma.

  3. Cmax of rivaroxaban granules for oral suspension vs. rivaroxaban tablet

    Time frame: From pre-dose up to 72 hours after drug administration.

    Cmax = maximum observed drug concentration in measured matrix after single dose administration

    Rivaroxaban Blood sampling for rivaroxaban pharmacokinetics in plasma.

Secondary outcomes

  1. Number of treatment-emergent adverse events

    Time frame: Up to 7-14 days after the last administration

    Adverse events occurring in the period between the signing of the informed consent and the end of the follow-up phase.

Sponsors and collaborators

Lead sponsor

Bayer

Industry

Registry information

Official study title

Single-dose, Open-label, Randomized, 2-way Crossover Bioequivalence Study of 20 mg Granules for Oral Suspension Rivaroxaban Versus 20 mg Tablets Rivaroxaban Under Fed Condition in Healthy Subjects

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
Jan 27, 2021
Registry last updated
Jan 27, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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