A Trial of Behavioral Intervention on Prognostic Survival of Patients With Unresectable Liver Cancer

Inclusion criteria

• Pathologically or radiologically confirmed primary hepatocellular carcinoma;
• BCLC stage B-C, initially assessed as unresectable;
• Age 18-75 years;
• ECOG performance status score 0-2;
• Child-Pugh classification grade A or B (<=9 points);
• Normal cognitive ability, capable of understanding and following intervention protocols;
• Both the patient and primary caregiver can use a smartphone and the WeChat platform and are able to complete questionnaires and follow-up tasks;
• Voluntarily participates in the study and signs the informed consent form.

Exclusion criteria

• Presence of malignant tumors in other organs;
• Presence of extrahepatic metastasis;
• Presence of any of the following severe organic diseases in any organ:

(1) Cardiovascular: NYHA class III-IV heart failure, acute coronary syndrome within the past 6 months; (2) Liver: Child-Pugh class C cirrhosis, or ALT/AST >5 times the upper limit of normal; (3) Kidney: eGFR <45 mL/min/1.73m^2 or dialysis-dependent; (4) Respiratory: respiratory failure requiring long-term oxygen therapy; (5) Hematologic: hemoglobin <9 g/dL or platelets <75×10^9/L; 4. History of psychiatric disorders, severe cognitive impairment, or substance abuse; 5. Previous liver transplantation or treatment for malignant liver tumors; 6. Complete thrombosis of the main portal vein; 7. Female patients who are pregnant or breastfeeding; 8. Presence of severe congenital or acquired immunodeficiency; 9. Unwillingness to sign the informed consent form; 10. Other conditions deemed unsuitable for participation in this study by the investigator.