A Trial of an Oral Nutritional Supplement in Older Hospitalized Patients - NOURISH Study

Inclusion criteria

• Male or female ≥ 65 years of age.
• Admitted to hospital with diagnosis of heart failure, acute myocardial infarction, pneumonia, or chronic obstructive pulmonary disease.
• Subjective Global Assessment rating of B or C.
• Length of hospital stay anticipated to be > 3 days and < 12 days
• Able to consume foods and beverages orally.
• Functionally ambulatory during the 30 days prior to admission.

Exclusion criteria

• Uncontrolled hypertension
• Diagnosis of diabetes
• Current active cancer or recently treated cancer
• Impaired renal function
• Liver failure, acute Hepatitis, or hepatic encephalopathy
• Active tuberculosis.
• HIV
• Disorder of gastrointestinal tract
• Autoimmune disorder
• Intubation, and/or tube or parenteral feeding.
• Severe dementia or delirium, brain metastases, eating disorder, history of significant neurological or psychiatric disorder, alcoholism, substance abuse or other conditions that may interfere with study product consumption or compliance with study protocol procedures
• Allergy or intolerance to any of the ingredients in the study products.
• Body mass index of ≥ 40 kg/m2.
• Resident in a nursing home or other residential facility.
• Planned surgery during course of the study.