A Trial Examining the Treatment of Common Warts With Combination Liquid Nitrogen (LN2) and Cantharidin

The purpose of the study was to see if liquid nitrogen, a commonly used treatment for warts, is more effective if it is used alone, or if it is more effective if combined with cantharidin, a topical treatment also commonly used for warts (verruca vulgaris).

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Key information

Conditions

Verruca Vulgaris DNA Virus Infections Infections Papillomavirus Infections Skin Diseases Skin Diseases, Infectious Skin Diseases, Viral Skin and Connective Tissue Diseases Tumor Virus Infections Virus Diseases Warts

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

North Idaho Dermatology

Coeur d'Alene, Idaho, 83814, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

common warts on non-genital, non-facial skin
otherwise healthy
between 18-65 and able to give informed consent
capable of tolerating treatment

Exclusion criteria

Ill-health
Poor tolerance or sensitivity to treatments in study
<18 years old; >65 years old
verruca plana or condyloma acuminata
immunosuppression or immune dysfunction
significant peripheral vascular disease
significant sensitivity to cold
epidermodysplasia verruciformis
mosaiform warts or periungual warts

Treatment and study plan

Liquid nitrogen and cantharidin

Drug

Liquid nitrogen applied to wart(s), then cantharidin 1% topical applied afterward.

Liquid nitrogen and topical placebo

Drug

Liquid nitrogen applied to wart(s), then placebo vehicle applied thereafter.

Primary outcomes

Percentage of common warts cleared

Time frame: 12 weeks

Percentage of treated warts cleared with treatment, as measured with dermatoscopic examination, after 12 weeks.

Sponsors and collaborators

Lead sponsor

North Idaho Dermatology

Other

Registry information

Official study title

A Randomized Clinical Trial Examining the Efficacy of Treatment of Cutaneous Verruca Vulgaris in Adult Patients With Combined Liquid Nitrogen Cryotherapy and Topically Applied Cantharidin

Important dates

Study start: 2007
Primary completion: 2008
Study completion: 2008
First posted: Mar 11, 2010
Registry last updated: Mar 11, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed