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Completed

NCT Number: NCT03613038

A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive Dysarthria

The goal is to improve the fundamental knowledge about articulatory motor performance in people with Lou Gehrig's disease (also known as ALS) and Parkinson's disease (PD), in order to develop more sensitive assessments for progressive speech loss, which may lead to the improved timing of speech therapies.

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Key information

Conditions

Amyotrophic Lateral Sclerosis Articulation Disorders Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Communication Disorders Dysarthria Language Disorders Metabolic Diseases Motor Neuron Disease Movement Disorders Nervous System Diseases Neurobehavioral Manifestations Neurodegenerative Diseases Neurologic Manifestations Neuromuscular Diseases Nutritional and Metabolic Diseases Parkinson Disease Parkinsonian Disorders Pathological Conditions, Signs and Symptoms Proteostasis Deficiencies Signs and Symptoms Speech Disorders Spinal Cord Diseases Synucleinopathies TDP-43 Proteinopathies

Age range

19 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Kansas Medical Center, Fairway, Kansas, United States

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About this study

The long-term goal is to optimize dysarthria assessment by improving the early detection and tracking of articulatory performance in progressive dysarthrias. The short-term goal of the proposed cross-sectional study is to focus on ALS and PD and quantify articulatory kinematic performance as a function of phonetic complexity, which is experimentally manipulated based on theoretical principles of speech motor development. The research strategy is to use 3D electromagnetic articulography to examine phonetic complexity effects of single word stimuli at the articulatory kinematic level in 15 talkers each with preclinical, mild, and moderate dysarthria, relative to 45 controls. The central hypothesis is that as dysarthria severity increases the discrepancy in articulatory performance, indexed by movement speed, distance, coordination, and variability, between people with dysarthria and typical controls will significantly increase at a lower phonetic complexity level.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • May or may not have a neurological impairment.
  • Age range of 19-90 years.
  • Male or female.
  • Provide written consent before any study specific procedures are performed.
  • Have ability to comply with basic instructions.
  • Monolingual English speaker.
  • Have ability to partake in a 90 minute data collection.

Exclusion criteria

  • Any speech, language, cognition, or hearing impairment prior to diagnosis of a neurodegenerative disease.
  • Anyone not appropriate for study participation, as deemed by the principal investigator.

Treatment and study plan

Phonetic complexity effects on speech motor performance

Behavioral

Use of 3D electromagnetic articulography to examine phonetic complexity effects of single word stimuli at the articulatory kinematic level in talkers each with preclinical, mild, and moderate dysarthria, relative to healthy controls.

Primary outcomes

  1. Peak movement speed

    Time frame: Up to 3 months after enrollment

    Peak speed (millimeters/second) for each articulatory marker is the maximum value of the first-order derivative of each marker's Euclidean distance time-history.

  2. Range of movement

    Time frame: Up to 3 months after enrollment

    The convex hull represents the smallest convex set containing all the points in the 3D motion path.

  3. Duration

    Time frame: Up to 3 months after enrollment

    Word duration (seconds) is the time between onset and offset of movement for each word.

  4. Spatiotemporal movement variability (STI)

    Time frame: Up to 3 months after enrollment

    STI is the most widely used metric to capture movement pattern variability during speech. To determine STI, the pattern of articulatory movements and the variability of that pattern over several repetitions of an utterance are examined.

  5. Inter-articulator coordination

    Time frame: Up to 3 months after enrollment

    Spatiotemporal coupling relations between articulators will be derived from vertical movements of the articulators using a covariance measure.

Sponsors and collaborators

Lead sponsor

University of Missouri-Columbia

Other

Collaborators

  • National Institute on Deafness and Other Communication Disorders (NIDCD)

Registry information

Official study title

Understanding Communication and Cognitive Impairments in Neurodegenerative Disorders

Important dates

Study start
2017
Primary completion
2022
Study completion
2022
First posted
Aug 2, 2018
Registry last updated
May 17, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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