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Completed

NCT Number: NCT06336005

A Study to See How Safe a New Medicine (NNC6022-0001) is in Healthy People

The study is testing a new study medicine, which is being tested as a potential medicine to treat cardiometabolic diseases.

The aim of this study is to see if the study medicine is safe, how it works in participants body, and what the body does to the study medicine.

Participants will either get NNC6022-0001 (the new study medicine) or placebo (a "dummy medicine" without the active ingredient). Which treatment participants get is decided by chance. The study medicine is a potential new medicine which cannot be prescribed by doctors.

The study will last for about 10 months in total.

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Key information

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

ICON - location Groningen

Groningen, 9728 NZ, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men or women of non-childbearing potential.
  • Age 18-55 years (both inclusive) at the time of signing the informed consent.
  • Body mass index (BMI) between 18.5 to 29.9 kg/m^2 (both inclusive) at screening.
  • Body Weight: Greater than or equal to 50 kg at screening.
  • Considered to be generally healthy based on the medical history, physical examination, and the results of vital signs, electrocardiogram and clinical laboratory tests performed during the screening visit, as judged by the investigator.

Exclusion criteria

  • Known or suspected hypersensitivity to study intervention(s) or similar products.
  • Any disorder, which in the investigator's opinion might jeopardise participant's safety or compliance with the protocol.
  • Any of the below laboratory safety parameters at screening outside normal range, see designated reference range documents for specific values:.
  • Alanine Aminotransferase (ALT) above upper normal limit (UNL)
  • Aspartate aminotransferase (AST) above UNL
  • Total Bilirubin (BL) above UNL
  • Creatinine above UNL
  • International normalized ratio (INR) above UNL
  • Fibrinogen outside normal range of 1.6 - 4.2 gram pr. Liter (g/L)
  • C-reactive protein (CRP) above 5 milligram pr. Liter (mg/L) (males) and above 8 mg/L (females)
  • Use of prescription medicinal products or vaccines within 14 days before dosing and/or non prescription medicinal products within 7 days before dosing.

Exceptions are: Topical medications not reaching systemic circulation; less than once per week of over-the-counter paracetamol, ibuprofen and/or acetylsalicylic acid at their labelled doses for mild pain; vitamins at their labelled doses.

Treatment and study plan

NNC6022-0001

Drug

Participants will recieve single ascending dose (SAD) of NNC6022-0001. Dose is given in escalating manner for up to seven cohorts.

Placebo (NNC6022-0001)

Drug

Participants will recieve single ascending dose (SAD) of placebo. Placebo is given in escalating manner for up to seven cohorts

Primary outcomes

  1. Number of treatment emergent adverse events (TEAE)

    Time frame: From time of dosing (Day 1) to end of study (Day 14)

    Number of events

Secondary outcomes

  1. AUC0-t, SD; the area under the NNC6022 0001 plasma concentration-time curve from time 0 to last measurable plasma concentration after a single dose

    Time frame: From pre-dose (Day 1) to end of exposure (Day 7)

    Hours*micrometer (hr×µM)

  2. AUC0-∞, SD; the area under the NNC6022 0001 plasma concentration-time curve from time 0 to infinity after a single dose

    Time frame: From pre-dose (Day 1) to end of exposure (Day 7)

    Hours*micrometer (hr×µM)

  3. Cmax, SD; the maximum plasma concentration of NNC6022 0001 after a single dose

    Time frame: From pre-dose (Day 1) to end of exposure (Day 7)

    Micrometer (µM)

  4. IL-1β, SD; ratio of <Timepoint> (time of the maximal plasma concentration of NNC6022 0001) to baseline

    Time frame: From pre-dose (Day 1) to estimated tmax (Day 1)

    Percentage (%)

Sponsors and collaborators

Lead sponsor

Novo Nordisk A/S

Industry

Registry information

Official study title

A First Human Dose Study to Assess the Safety, Tolerability, Pharmacokinetics and Target Engagement of Single Doses of NNC6022-0001 in Healthy Adults.

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Mar 28, 2024
Registry last updated
Jun 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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