A Study to Learn About the Study Medicine (Called Maplirpacept (PF-07901801)) in Japanese With Hematologic Malignancies

CD47 is a cell-surface protein expressed on multiple normal cell types and often at high levels on many malignant tumor cells. Maplirpacept (PF-07901801) is a soluble recombinant fusion protein created by directly linking the sequences encoding the CD47 binding domain of human Signal Regulatory Protein alpha with the fragment crystallizable domain of human Immunoglobulin 4. maplirpacept (PF-07901801) functions as a soluble decoy receptor, preventing CD47 from delivering its antiphagocytic signal. Neutralization of the inhibitory CD47 signal enables macrophage activation and anti-tumor effects by pro-phagocytic signals present on the tumor cells.

The objective of this study is to confirm safety and tolerability of single agent maplirpacept (PF-07901801) at the recommended phase 3 dose in Japanese participants with relapsed or refractory lymphoma or multiple myeloma.

Inclusion criteria

• Relapsed or refractory lymphoma (Hodgkin's or non-Hodgkin's) or multiple myeloma
• Disease must have progressed with standard anticancer therapies
• measurable disease
• Capable of giving signed informed consent
• Eastern cooperative oncology group performance status 0 or 1
• Adequate organ functions

Exclusion criteria

• Known, current central nervous system or interstitial lung disease involvement
• History of hemolytic anemia or positive direct antiglobulin test or active bleeding disorder
• Chronic use of systemic corticosteroids of more than 20 mg/day of prednisone or equivalent
• Significant cardiovascular disease
• Other significant medical condition unrelated to the primary malignancy
• Radiation therapy within 14 days of study treatment administration
• Hematopoietic stem cell transplant within 90 days before the planned start of study treatment
• Antiplatelet/anticoagulant agents within 14 days before planned start of study treatment
• Patients sustaining major surgery at least 4 weeks prior to study enrollment
• Use of any investigational agent or any anticancer drug within 14 days before planned start of study treatment
• Prior anti-CD47 and anti-Signal Regulatory Protein alpha therapy
• Active, uncontrolled bacterial, fungal, or viral infection
• Investigator site staff directly involved in the conduct of the study and their family members