A Study to Evaluate the Safety, Pharmacokinetics of AD-118 and AD-1181 in Healthy Adult Subjects

A Study to Evaluate the Safety and Pharmacokinetics of AD-118 and AD-1181 Under Fasted Conditions in Healthy Adult Subjects

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Key information

Conditions

Chronic Heart Failure

Age range

19 year–64 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

H Plus Yangji Hospital

Seoul, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Body weight equal to or greater than 50kg and Body mass index (BMI) between 18.0 kg/m2 and 30.0 kg/m2 at the time of screening visit
Subjects aged 19 years or older and under 65 years at the screening visit

Exclusion criteria

Participation in another clinical study with an investigational drug within the 6 months from scheduled first administration
Other exclusions applied

Treatment and study plan

AD-118, AD-1181

Drug

Single-dose oral administration of AD-118, according to randomized treatment sequence in a 2-period crossover design.

Primary outcomes

Area under the plasma concentration-time curve during dosing interval (AUCt)

Time frame: [Time Frame: pre-dose (0hour) to 36hours]

AUCt of AD-118
Maximum concentration of drug in plasma (Cmax)

Time frame: Time Frame: pre-dose (0hour) to 36hours]

Cmax of AD-118

Study contacts

Contact information is provided by the study sponsor or research team.

JaeHun Jung

CONTACT

[email protected]

+82-31-891-5683

Sponsors and collaborators

Lead sponsor

Addpharma Inc.

Industry

Registry information

Official study title

An Open-label, Randomized, Fasting, Single-dose, 2-sequence, 2-period, Crossover Study to Evaluate the Safety and the Pharmacokinetics of AD-118 Compared to AD-1181 in Healthy Adult Volunteers

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Jul 21, 2026
Registry last updated: Jul 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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