A Study to Evaluate the Efficacy and Safety of HCP2102 in Essential Hypertension Patients

Inclusion criteria

• Patients aged ≥ 19 years
• Patients who understands the process of clinical study and voluntarily signs a peer letter
• Visit 1: A person whose blood pressure measured in visit 1 corresponds to the following conditions

• Blood pressure medication taken patients: 140mmHg ≤ sitSBP<200mmHg, sitDBP<120mmHg
• Blood pressure medication free patients: 160mmHg ≤ sitSBP<200mmHg, sitDBP<120mmHg
• Visit 2: 140mmHg ≤ sitSBP<200mmHg, sitDBP<120mmHg

Exclusion criteria

• Difference between arms greater than 20 mmHg for mean sitSBP or 10 mmHg for mean sitDBP
• Orthostatic hypotension with symptoms within 3 months prior to visit 1
• Secondary hypertension patient or suspected to be
• Uncontrolled diabetes mellitus(HbA1c > 9%) or type I diabetes mellitus
• Active gout or hyperuricemia (uric acid ≥ 9mg/dL)
• Severe heart disease or severe neurovascular disease
• Severe or malignant retinopathy
• Clinically significant hematological finding
• Severe renal diseases (eGFR<30mL/min/1.73m2)
• Severe hepatopathy or active hepatopathy (AST or ALT normal range ≥ 3 times)
• Hypokalemia or Hyperkalemia(K<3.5mmol/L or K ≥ 5.5mmol/L)
• Hyponatremia or Hypernatremia(Na<135mmol/L or Na ≥ 155mmol/L)
• Hypercalcemia(Ca ≥ 10.5mg/dL)
• History of malignancy tumor
• History of autoimmune disease
• History of alcohol or drug abuse
• Positive to pregnancy test, nursing mother, intention on pregnancy
• Considered by investigator as not appropriate to participate in the clinical study with other reason