A Study to Evaluate the Efficacy and Safety of Boceprevir Added to Standard of Care Therapy in Previously Treated Participants With Chronic Hepatitis C Genotype 1 and Cirrhosis (MK-3034-105)

Inclusion criteria

• Weight between 40 kg and 125 kg
• Documented CHC genotype 1 infection
• Previous course of treatment with SOC (PegIFN-2a or PegIFN-2b + RBV) with a documented non-response
• Documented diagnosis of cirrhosis
• No evidence of hepatocellular carcinoma (HCC) by ultrasound
• Participant and partner of participant must agree to use 2 effective contraceptives as specified for at least 2 weeks prior to Day 1 of treatment and continue until at least 6 months after last dose of study drug (7 months for male participants)

Exclusion criteria

• Co-infection with human immunodeficiency virus (HIV) or hepatitis B virus
• Use of any investigational drugs within 30 days prior to study enrollment
• Participation in any other clinical trial within 30 days of study enrollment or intention to participate in another clinical trial during this study
• Evidence of present or previous decompensated liver disease including, but not limited to, a history or presence of clinical ascites or hepatic encephalopathy. Only participants with large (F3) esophageal varices, as determined in an esophagogastroduodenoscopy (EGD) performed within the past 12 months according to international guidelines will be excluded.
• Clinically significant ocular examination findings
• Pre-existing significant psychiatric condition(s)
• Clinical diagnosis of active or recent substance abuse
• Evidence of active or suspected malignancy, or a history of malignancy, within the last 3 years (except adequately treated carcinoma in situ and basal cell carcinoma of the skin)