A Study to Evaluate Efficacy of Different Natural Ingredients in Improving Gut Health in Adults With Leaky Gut.

Inclusion criteria

• Male and female individuals with the age ≥18 and ≤65 years with moderate physical activity level as per International Physical Activity Questionnaire - Short Form (IPAQ-SF)
• Body mass index > 18 and < 29.9 kg/m2
• Individuals with at least once/ week complains of ≥ 3 of following gastrointestinal symptoms since last three months: dyspepsia, diarrhea, constipation, heartburn, nausea, acid reflux, bloating.
• Individuals agreeing to consume four tablets (325 mg each) of aspirin twice within a 12-hour period
• Individuals with fasting blood glucose levels ≤ 125 mg/dL
• Individuals with availability of western toilet at their homes for stool sample collection
• Individuals who are literate enough to understand the essence of study, are informed about the purpose of the study, and understand their rights.
• Individuals who are able to give written informed consent and are willing to participate in the study.

Exclusion criteria

• Individuals diagnosed with IBS including IBS-Constipation, IBS-Mixed, IBS-Diarrhea or Unclassified
• Allergy to aspirin
• Use of medications in the last 2 weeks prior to the pre-baseline period. This does not include birth control pills or standard multi-vitamin/mineral supplements
• Performing high intensity exercise regularly using IPAQ- SF
• Daily use of NSAIDs in the last 3 months or incidental use in the last 2 weeks prior to screening
• Unwillingness to avoid the use of antidiarrheal or laxative medication on a regular or an "as-needed basis" during the full length of the study
• Abnormal Thyroid Stimulating Hormone (TSH) value which is < 0.40 or > 4.50 μIU/mL
• Individuals with uncontrolled type II DM defined as FBG > 125 mg/ dL
• Presence of uncontrolled hypertension defined as SBP ≥ 140 mm Hg and/or DBP ≥ 90 mm Hg with or without anti-hypertensives
• Individuals on high-fiber/ fodmap diet
• Individuals with known diagnosis of helicobacter pylori infection
• Individuals with a history of surgical resection of the stomach, small intestine or large intestine
• Individuals with a history of or complications from inflammatory bowel disease (Crohn's disease or ulcerative colitis) and ischemic colitis
• Current smokers
• Use of another investigational product within 3 months of the screening visit
• History or current impaired cardiovascular circulation or uncontrolled hypertension, diabetes, bleeding tendencies, kidney, liver or chronic respiratory diseases including asthma, or any other disease, that by the investigators' discretion could interfere with the intestinal barrier function of the subject
• Individuals who used probiotics, prebiotics, antibiotics, prokinetics, laxatives, suppositories or enemas in the last 3 months
• Individuals with a history of any diet-based intolerance (gluten or lactose intolerance)
• Individuals with a history of or complications from malignant tumors.
• History of any significant neurological and psychiatric condition which may affect the participation and inference of the study's end points.
• Use of recreational drugs (such as cocaine, methamphetamine, marijuana, etc.)/Nicotine dependence.
• High-risk drinking as defined by consumption of 4 or more alcohol containing beverages on any day or 8 or more alcohol containing beverages per week for women and 5 or more alcohol containing beverages on any day or 15 or more alcohol containing beverages per week for men
• Individuals who have clinically significant following illness, i.e., Cardiovascular, endocrine system, immune system, respiratory system, hepatobiliary system, kidney and urinary system, neuropsychiatric, musculoskeletal, inflammatory, blood and tumors, other gastrointestinal diseases, etc
• Females who are pregnant/planning to be pregnant/lactating or taking any oral contraceptives
• Any condition that could, in the opinion of the investigator, preclude the participant's ability to successfully and safely complete the study or that may confound study outcomes.