A Study to Compare the Pharmacokinetic Profile of a Proprietary Curcumin Forumulation to a Comparator Curcumin Product

Inclusion criteria

• Male and females 18-45 years of age
• If female, subject is not of child bearing potential, which is defined as females who have had a hysterectomy or oophorectomy, bilateral tubal ligation or are post-menopausal (natural or surgically with > 1 year since last menstruation) OR

Females of childbearing potential must agree to use a medically approved method of birth control and have a negative urine pregnancy test result. Acceptable methods of birth control include:

• Hormonal contraceptives including oral contraceptives, hormone birth control patch (Ortho Evra), vaginal contraceptive ring (NuvaRing), injectable contraceptives (Depo-Provera, Lunelle), or hormone implant (Norplant System)
• Double-barrier method
• Non-hormonal intrauterine devices
• Vasectomy of partner
• BMI 18-29.9 kg/m2 (±1 kg/m2)
• Healthy as determined by laboratory results and medical history
• Agrees to maintain current level of physical activity throughout the study
• Agree to avoid using black or white pepper, turmeric, curcumin or curry in the preparation of food for 7 days prior to randomization and throughout the study period.
• Agree to avoid Indian and Thai cuisines for the period of the study
• Agree to avoid food with yellow dye #E100
• Agrees to avoid alcohol, caffeine 12 hours and grapefruit and grapefruit juice 48 hours prior to baseline and each subsequent clinic visit
• Agrees to consume only low polyphenols in the diet (nutritionists will counsel on high polyphenol fruits, vegetables to avoid, wine, beer, supplements, herbal extracts, and whole-grain based foods) 3 days prior to baseline and on test days (meal options and lists of foods to avoid will be provided to subjects by nutritionists)
• Has given voluntary, written, informed consent to participate in the study

Exclusion criteria

• BMI ≥ 30 kg/m2
• Women who are pregnant, breastfeeding, or planning to become pregnant during the course of the trial.
• Unstable medical conditions as determined by the Qualified Investigator
• Use of natural health products containing turmeric or curcumin within 7 days prior to randomization and during the course of the study
• Use of St Johns Wort 3 weeks prior to baseline and during the study
• Subjects who are smokers
• Subjects with current or history of gastrointestinal problems or disease
• Metabolic, endocrine, or chronic diseases
• Immunocompromised individuals such as subjects that have undergone organ transplantation or subjects diagnosed with human immunodeficiency virus (HIV)
• Clinically significant abnormal lab results at screening (e.g. AST and/or ALT > 2 x ULN, and/or bilirubin > 2 x ULN) will be assessed by the Qualified Investigator
• Subjects who have planned surgery during the course of the trial
• History of or current diagnosis of any cancer (except for successfully treated basal cell carcinoma) diagnosed less than 5 years prior to screening. Subjects with cancer in full remission more than 5 years of diagnosis are acceptable.
• History of gallbladder issues, hyperacidity, gastric/duodenal ulcers.
• Prior use of prescription H2 blocker, proton pump inhibitor or blood sugar-lowering agents
• Use of blood pressure medication
• Subjects on restrictive dietary regimens
• Blood donation in the last 2 months
• History of blood/bleeding disorders or taking prescription blood thinners or anti-platelet therapy
• Alcohol abuse (>2 standard alcoholic drinks per day) or drug abuse within the past 6 months
• Use of medical marijuana
• Clinically significant abnormal laboratory results at screening
• Participation in a clinical research trial within 30 days prior to randomization
• Allergy or sensitivity to study supplement ingredients or to any food or beverage provided during the study
• Individuals who are cognitively impaired and/or who are unable to give informed consent
• Any other condition which in the Investigator's opinion may adversely affect the subject's ability to complete the study or its measures or which may pose significant risk to the subject