A Study to Characterize Puff Topography With Use of JUUL 5% Electronic Nicotine Delivery Systems (ENDS) in Adult Smokers

This will be an open label study to evaluate puff topography in adult smokers using a JUUL 5% ENDS. Up to 30 subjects will be enrolled and evaluated on Day 1 and Day 15. The duration of the study is 15 days with up to a 28 days screening window.

Key Inclusion Criteria:

• Healthy, adult, male or female smoker, 21 to 65 years of age
• Has been a smoker for at least 12 months prior to Screening.
• Currently smokes an average of 5 to 40 manufactured combustible (menthol or non menthol) cigarettes per day.
• A female subject of childbearing potential must have been using 1 of the following forms of contraception and agree to continue using it through completion of the study
• Provides voluntary consent to participate in this study documented on the signed informed consent form.

Key Exclusion Criteria:

• Has a clinically significant abnormal finding on the physical examination, medical history, vital signs, ECG, or clinical laboratory results, in the opinion of the PI.
• Has a body mass index (BMI) > 40 kg/m2 or < 18 kg/m2 at Screening.
• Has a history of drug or alcohol abuse within 24 months of Day 1.
• If female, the subject is pregnant, lactating, or intends to become pregnant during the time period from Screening through the end of study.