Skip to main content
OpenTrials
Completed

NCT Number: NCT02909075

A Study to Assess Thymic Function Using PET/CT and MRI

The purpose of this study is to see if a positron emission tomography/computed tomography (PET/CT) scan and a magnetic resonance imaging (MRI) of the chest can assess changes in the thymus size and function. The researchers would like to monitor the thymus with a PET/CT scan and a MRI before and after the participants transplantation.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

CD34 Selected Peripheral Blood Stem Cell Graft

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Memorial Sloan Kettering Cancer Center, Basking Ridge, New Jersey, United States

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient's age is ≥18 or ≤65 years old.
  • Patients must have a plan to receive a CD34-selected peripheral blood stem cell graft.

Exclusion criteria

  • Patient is not able to undergo MR imaging due to any contraindication to MRI based on departmental MR questionnaire (e.g. past gadolinium allergies, failure of metallic screening, claustrophobia, inability to lay flat for duration of the study, inability to hold breath, etc.)
  • Pregnant or breastfeeding.

Treatment and study plan

PET/CT scans

Device

MRI

Device

Primary outcomes

  1. change in thymic size

    Time frame: 1 year

    A clinically meaningful change is defined as increase in thymic size (> 0.2cm increase in uni-dimensional diameter), functional volume (>10%) or uptake (≥25%). We will report proportion of patients with each component of clinically meaningful change, as well as the proportion with at least one component, along 95% exact confidence intervals.

Sponsors and collaborators

Lead sponsor

Memorial Sloan Kettering Cancer Center

Other

Registry information

Official study title

An Initial Study of FDG-PET/CT and MRI to Assess Thymic Function

Important dates

Study start
2016
Primary completion
2020
Study completion
2020
First posted
Sep 21, 2016
Registry last updated
Jan 27, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.