A Study to Assess the Safety & Interaction Between GW679769, Dexamethasone, & Ondansetron When Taken by Healthy Adults

Inclusion criteria

• Healthy adult males or females
• Age: 18 to 55 years, inclusive
• A female subject who is non-childbearing potential or using acceptable contraceptive methods.
• Adequate organ systems function
• Able to swallow and retain oral medication
• Able to understand and comply with protocol requirements and instruction and is likely to complete the study.

Exclusion criteria

• Cannot participation if subject has a clinically relevant abnormality, medical condition, or circumstance that makes them unsuitable for the study per the study doctor.
• History of drug or other allergy which, in the opinion of the Investigator, contraindicates participation.
• Use of an investigation drug within 28 days or 5 half-lives.
• Blood donation in excess of 500mL within 56 days prior to dosing or intends to donate within 30 days of the post-treatment follow-up visit.
• Presence of or suspected iron deficiency
• Positive stool for occult blood
• Female subject who is lactating
• Positive urine drug screen
• Positive for HIV antibody, hepatitis C antibody or hepatitis B surface antigen
• Use of tobacco-containing products within the past 12 months prior to screening
• History of drug or alcohol abuse or dependence within 6 months of screening
• History or presence of uncontrolled emesis
• Positive purified protein derivative (PPD) skin test for tuberculosis