A Study on Intima Media Thickness (IMT) in Middle-aged Subjects

This is an observational study to measure the thickness of artery walls in the neck (intima media thickness IMT) by ultrasound examination in middle-aged subjects with central obesity. The purpose of this study is to obtain local data how common asymptomatic atherosclerosis is, and to investigate the association between Cardiovascular Disease risk factors and intima media thickness (IMT) in the Hong Kong population. Results from this study may enhance the public awareness of asymptomatic atherosclerosis and understand its role in the development of Cardiovascular Disease in Hong Kong.

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Key information

Conditions

Atherosclerosis Arterial Occlusive Diseases Arteriosclerosis Body Weight Cardiovascular Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Obesity, Abdominal Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Vascular Diseases

Age range

45 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Research Site

Hong Kong

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Male or female aged 55 years or above.
Waist circumference: male more than 90 cm; female more than 80 cm.

Exclusion criteria

Any known chronic diseases requiring long-term medication such as hypertension, diabetes and hyperlipidemia.
Presence of known cardiovascular diseases including cerebro-vascular disease, coronary heart disease and peripheral artery disease.
Presence of any active major diseases that may interfere the physical conditions and body weight of subjects during the study period, which include malignancy, infection, renal or liver function impairment, recent major surgery (within 3 months).

Treatment and study plan

Primary outcomes

To investigate the prevalence of asymptomatic atherosclerosis by measurement of intima media thickness (IMT) in middle-aged subjects with central obesity in Hong Kong,

Time frame: during the one single study visit

Secondary outcomes

To examine the association between IMT value and cardiovascular disease (CVD) risk factors, and blood lipid and glucose profiles in middle-aged centrally obese subjects in Hong Kong.

Time frame: During the one single study visit
IMT results to be compared with what being reported in the recent literature on normal Chinese population.

Time frame: During the one single study visit

Sponsors and collaborators

Lead sponsor

AstraZeneca

Industry

Registry information

Acronym: IMT

Important dates

Study start: 2008
Study completion: 2009
First posted: Nov 3, 2008
Registry last updated: Jan 12, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed