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NCT Number: NCT06707948

A Study on Different Treatments for Knee Osteoarthritis Caused by Damaged Roots of the Medial Meniscus.

Medial meniscus posterior root tears (MMPRT) account for 20% or more of all meniscus tears, but the diagnosis and treatment of this condition continues to plague the general population due to the complexity of the diagnosis and uncertainty of the treatment. Early as well as timely diagnosis and treatment is one of the effective ways to avoid accelerated knee degeneration. Based on this study, our team is going to conduct a clinical study on posterior medial meniscus tear, combining Magnetic Resonance Imaging(MRI) to dynamically assess the changes of meniscus and articular cartilage surface after the injury, and selecting a specific patient group to carry out different therapeutic interventions, which mainly include conservative treatment, partial meniscectomy, and meniscal repair, in order to clarify the effects of different treatment modalities on the articular cartilage after the posterior meniscus tear, and to help to delay the degeneration of knee joints. This is to clarify the effects of different treatment modalities on the articular cartilage after posterior medial meniscus tears and to provide appropriate advice for delaying the progression of osteoarthritis of the knee.

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Key information

Conditions

Osteoarthritis Arthritis Joint Diseases Meniscus Lesion Musculoskeletal Diseases Rheumatic Diseases

Age range

50 year–65 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of posterior root tear of the medial meniscus;
  • Patients with K-L classification ≤ grade II;
  • The age range of 50-65 years old;
  • International Cartilage Repair Society (ICRS) Modified Magnetic Resonance Imaging Grading System ≤ Grade 2;
  • International Cartilage Repair Society (ICRS) arthroscopic grading system ≤ grade 2;
  • Knee joint mobility ≥90°;
  • Inversion deformity ≤10°;
  • Must be able to complete follow-up MRI within 2 years after knee meniscus surgery;
  • Must be able to complete clinical data;

Exclusion criteria

  • Can not participate in this study;
  • Patients with concomitant meniscal injuries elsewhere;
  • knee joint infection disease;
  • Osteoporosis disease;
  • Patients with previous history of knee surgery;
  • Knee joint instability disease;
  • Severe KOA disease;
  • Can not cooperate with MRI detection;
  • Cannot tolerate the surgery;
  • Those who cannot tolerate the arthroscopic knee surgery;
  • Neuromuscular system pathology disease;

Treatment and study plan

Arthroscopic meniscus surgery

Procedure

Comparison of the incidence of osteoarthritis with conservative treatment as well as arthroscopic partial resection as well as arthroscopic repair surgery for a condition known as posterior meniscus root injury.

Primary outcomes

  1. the incidence of KOA

    Time frame: 30th November 2024 -30th November 2027

Secondary outcomes

  1. Articular cartilage T2-mapping value

    Time frame: 30th November 2024 -30th November 2027

    Articular cartilage T2 mapping values, post-standardised range 0-1

Other outcomes

  1. VAS (visual analogue scale)，VAS score

    Time frame: 30th November 2024 -30th November 2027

    The specific scoring method is to draw a 10 cm horizontal line on top of the paper, with 0 at one end of the line indicating no pain, 10 at the other end indicating severe pain, and the middle portion indicating varying degrees of pain.

  2. Lysholm score

    Time frame: 30th November 2024 -30th November 2027

    The score consists of eight indicators: pain (25 points), instability (25 points), atresia (15 points), swelling (10 points), limp (5 points), stair climbing (10 points), squatting posture (5 points), and the use of supports (5 points), with a total score of 100, with higher scores representing better knee function. 95 points or more is considered excellent, 94-85 points is good, 84-65 points is fair, and less than 65 points is poor. A score of less than 65 is poor.

  3. HSS (Hospital for Special Surgery) Score

    Time frame: 30th November 2024 -30th November 2027

    The score is out of 100 and consists of pain (30 points), function (22 points including walking and stair climbing), knee mobility (18 points), muscle strength (10 points), flexion deformity (10 points), joint stability (10 points), and deductions (-5 points). The higher the score, the better the knee function.

Study contacts

Contact information is provided by the study sponsor or research team.

Haifeng Zhang, Ph.D

CONTACT

[email protected]

86-15216619279

Yinxian Yu, Ph.D

CONTACT

[email protected]

86-1502179842

Sponsors and collaborators

Lead sponsor

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Other

Registry information

Official study title

Comparison of Different Treatment Strategies for Root Injury Behind the Medial Meniscus to Delay the Progression of Knee Osteoarthritis: a Prospective Cohort Study

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Nov 27, 2024
Registry last updated
Nov 27, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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