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NCT Number: NCT06513780

A Study of the Correlation Between Portal Vein Thrombosis and Prognosis of Liver Transplantation

The goal of this observational study is to investigate the correlation between portal vein thrombosis (PVT) and the prognosis of liver transplantation. The main questions it aims to address are:

What is the prevalence of PVT? What are the risk factors associated with PVT? What is the prognostic impact of preoperative PVT on liver transplantation?

Participants are divided into two groups: the PVT group and the non-PVT group. The investigators will comparatively analyze the data of both groups, estimate the prevalence and risk factors of PVT, construct a predictive model for PVT that is applicable in clinical settings, and clarify the prognostic effects of PVT.

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Key information

Conditions

Portal Vein Thrombosis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Beijing Friendship Hospital, Capital Medical University

Beijing, China

Location status: Recruiting

Location contact

Ruzhou Cai

CONTACT

[email protected]

18722563616

About this study

The investigators aim to investigate the prevalence and risk factors of PVT, to develop a novel grading or rating system for PVT, and to explore the prognostic impact of preoperative PVT in liver transplantation.

The investigators will:

Recruit patients according to the inclusion/exclusion criteria and obtain signed informed consents. They will collect demographic and laboratory characteristics and classify patients into the PVT group and the non-PVT group based on preoperative ultrasound and/or computed tomography.

Collect patients' perioperative medical imaging, surgical procedures, pathology reports, postoperative treatments, follow-up data, and clinical endpoints.

Comparatively analyze the data of the PVT and non-PVT groups, estimate the prevalence and risk factors of PVT, construct a predictive model for PVT that is applicable in clinical settings, clarify the prognostic effects of PVT, and propose a grading/rating system for PVT.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Liver transplantation recipients
  • Aged 18 years or older.

Exclusion criteria

  • Retransplantation
  • Multi-organ transplantation
  • Portal vein tumor thrombus

Treatment and study plan

observation

Other

No intervention were made.

Primary outcomes

  1. Death

    Time frame: 10 years

    Rate of death from various causes after liver transplant

  2. Postoperative portal vein thrombosis

    Time frame: 10 years

    Number of participants with portal vein thrombosis after liver transplant

  3. Postoperative portal vein stenosis

    Time frame: 10 years

    Number of participants with portal vein stenosis after liver transplant

Secondary outcomes

  1. Postoperative complications

    Time frame: 1 year

    Rate of re-surgery, interventional operation, endoscopy, dialysis, etc.

Study contacts

Contact information is provided by the study sponsor or research team.

Ru-zhou Cai, M.D.

CONTACT

[email protected]

18722563616

Sponsors and collaborators

Lead sponsor

Ru-zhou Cai

Other

Registry information

Important dates

Study start
2016
Primary completion
2025
Study completion
2025
First posted
Jul 22, 2024
Registry last updated
Sep 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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