A Study of the Association Between Tobacco Smoking and Bipolar Affective Disorder

The purpose of this study is to examine whether tobacco smoking is associated with bipolar affective disorder (severity of depressive and manic symptoms, presence of psychotic symptoms, history of a suicide attempts and other clinical features.)

Completed

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Key information

Conditions

Bipolar Disorder Behavior Bipolar and Related Disorders Mental Disorders Mood Disorders Smoking

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Tirat Carmel Mental Health Center

Tirat HaCarmel, 30200, Israel

About this study

An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology. Only a few small descriptive studies have examined the prevalence and correlates of tobacco use among bipolar patients with conflicting results. Patients who smoke score higher on rating scales for psychotic symptoms than their non-smoking peers. While the association of smoking with psychotic symptomatology in schizophrenia is established, such association according to bipolar affective disorder has been reported in a few studies and remains unclear. Also a few studies reported about association of smoking with depressive and manic symptoms, and with suicidal behavior in bipolar patients. Thus further investigation of these issues is warranted.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age 18-65 male or female
DSM -IV criteria for bipolar I affective disorder
Ability and willingness to sign informed consent for participation in the study

Exclusion criteria

Unwillingness or inability to participate in the study

Treatment and study plan

Primary outcomes

Relationship between smoking and other factors including: bipolar subtype, current and past clinical status, illness severity,history of a suicide attempts, age of bipolar onset, gender, education, social class, economic status.

Time frame: One interview session

Sponsors and collaborators

Lead sponsor

Tirat Carmel Mental Health Center

Other Gov

Registry information

Official study title

Association Between Tobacco Smoking and Bipolar Affective Disorder.Clinico-epidemiological, Cross-sectional, Retrospective Study.

Important dates

Study start: 2007
Primary completion: 2009
Study completion: 2009
First posted: Aug 26, 2008
Registry last updated: Jul 26, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed