A Study of TAK-279 in Healthy Chinese Adults

Inclusion criteria

• Participant is willing to participate and is capable of giving informed consent.
• Healthy, male or female participants of Chinese descent 18 to 45 years of age, inclusive, at the time of informed consent.
• Female participants meets the following contraception requirements: A surgically sterile female participant; or a female participant of nonchildbearing potential with laboratory confirmation of postmenopausal status (that is follicle-stimulating hormone levels greater than [>] 40 milli-international units per milliliter [mIU/mL]); or, if sexually active with a non-sterilized male partner, a female participant who agrees to use a highly effective method of contraception from the signing of informed consent throughout the duration of the study and for 10 days after the last dose. Male participants must agree to comply with effective contraceptive requirements.
• Body mass index greater than or equal to (>=) 18.0 kilogram per meter square (kg/m^2) and less than or equal to (<=) 28.0 kg/m^2 at the screening visit.
• Medically healthy with no clinically significant medical history, physical examination, laboratory profiles, vital signs, or electrocardiograms [ECGs], as deemed by the principal investigator (PI) or designee, including the following:

• Seated blood pressure (BP) (systolic BP/diastolic BP) >=90/50 millimeters of mercury (mmHg) and <=140/90 mmHg at the screening visit.
• Seated heart rate or pulse is >=50 beats per minute (bpm) and <=100 bpm at the screening visit.
• ECG findings are considered normal or not clinically significant by the PI or designee at the screening visit.
• Participant must be willing and able to understand and fully comply with all study procedures and must be available for the duration of the study.

Exclusion criteria

• Site personnel or their family.
• History or presence of clinically significant medical or psychiatric condition or disease.
• History of any illness or condition that might confound the results of the study or poses an additional risk to the participant by their participation in the study.
• History of allergy to study drug or any of its components.
• History of stomach or intestinal surgery or resection that would potentially alter absorption and/or excretion of orally administered drugs (uncomplicated appendectomy and hernia repair will be allowed).
• Clinical laboratory values at the time of screening or at check-in:

• Aspartate aminotransferase (AST) or alanine transaminase (ALT) >1.5 * the upper limit normal (ULN).
• Creatine phosphokinase (CPK) > the ULN.
• Hemoglobin <11.0 grams per deciliter (g/dL) (<110.0 gram per liter [g/L]).
• Absolute neutrophil count <1.8*10^9/liters (L) (<1800 per cubic millimeter [/mm^3]).
• Absolute lymphocyte count <0.8*10^9/L (<800/mm^3).
• Platelet count <100*10^9/L (<100,000/mm^3).
• A participant with out-of-range values may have the test repeated once at each time point (screening or check-in) and the participant may be enrolled if the repeated values are within protocol-specified ranges.
• Ingestion of Seville orange- or grapefruit-containing foods or beverages within 7 days prior to check-in.
• History of alcohol abuse or drug/chemical abuse within 2 years prior to check-in.
• Continuous smoker who has used nicotine- or tobacco-containing products within 1 month prior to the first dosing based on participant self-reporting.
• Female participants who have a positive pregnancy test result at the screening visit or at check-in, are planning to become pregnant during the study or are lactating.
• Positive results for urine drug test at the screening visit or at check-in.
• Herpes infections:

• Participants has active herpes virus infection, including herpes zoster or herpes simplex 1 and 2 (demonstrated on physical examination and/or medical history) at screening or check-in.
• Participants has a history of serious herpetic infection that includes any episode of disseminated disease, multi-dermatomal herpes zoster virus, herpes encephalitis, ophthalmic herpes, or recurrent herpes zoster (defined as 2 episodes within 2 years).
• Positive results for non-herpetic viral diseases at the screening visit:

• Participant has presence of hepatitis C virus (HCV) antibody or a positive confirmatory test result for HCV RNA (Ribonucleic acid) test or polymerase chain reaction (PCR).
• Participant has presence of positive result for hepatitis B surface antigen, presence of hepatitis B virus deoxyribonucleic acid, or positive anti-hepatitis B core antibody without concurrent positive hepatitis B surface antibody.
• Participant has positive results for human immunodeficiency virus.
• Positive results for Tuberculosis (TB) at the screening visit:

• The participant has a history of active TB infection, regardless of treatment status.
• The participant has signs or symptoms of active TB (including but not limited to chronic fever, chronic productive cough, night sweats, or weight loss) as judged by the investigator.
• The participant has evidence of latent TB as evidenced by a positive QuantiFERON-TB Gold (QFT) result or tuberculosis-specific enzyme-linked immunospot assay (T-Spot) OR 2 indeterminant QFT results or 2 borderline T-Spot results.
• The participant has had any imaging study during or 6 months prior to screening, including x-ray, chest computed tomography, magnetic resonance imaging, or other chest imaging suggesting evidence of current active or a history of TB.
• Positive result for Coronavirus disease 2019 (COVID-19) PCR test at the screening visit.
• Prior and concomitant therapy:

• Participants who received a live or live-attenuated vaccine in the 60 days prior to study drug administration. Administration of nonlive-attenuated vaccines or boosters for COVID-19 (for example [eg,] RNA-based vaccines, inactivated adenovirus-based vaccines, protein-based vaccines) in the 14 days prior to first dosing. The study site should follow local guidelines related to COVID-19.
• Use or intent to use any medications/products known to alter drug absorption, metabolism, or elimination processes, including CYP3A4 and/or P-glycoprotein (P-gp) inhibitors or inducers and St. John's wort, within 30 days prior to check-in.
• Use or intent to use any prescription medications/products or over-the-counter (OTC) medications within 14 days prior to check-in.
• Use or intent to use any nonprescription medications/products including phyto-therapeutic/herbal/plant-derived preparations within 14 days prior to check-in
• Donation of blood or significant blood loss within 56 days prior to study drug administration. Plasma donation within 7 days prior to the first dosing.
• Participation in another clinical study and having received its study drug within 30 days or 5 elimination half-lives prior to study drug administration. The 30-day or 5 elimination half-lives window will be derived from the date of the last blood collection or dosing, whichever is later, in the previous study to Day 1 of the current study.