A Study of Single and Multiple Doses of HRS-6257 in Healthy Subjects

Inclusion criteria

• Aged between 18 and 55 years old (based on the time of signing the informed consent form), both males and females are eligible.
• The body weight of males ≥ 50 kg, and that of females ≥ 45 kg, and body mass index (BMI): 19 - 28 kg/m².
• Female subjects must be non-pregnant or non-childbearing potential;
• Subjects must understand the study procedures and methods, voluntarily participate in this study and sign the ICF in person.

Exclusion criteria

• History of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological disease;
• Known or suspected hypersensitivity to trial product(s) or related products;
• 12-lead ECG demonstrating QTcF >450 msec or history or risk factors for QT prolongation;
• Blood donation of more than 200 mL within the last 6 months
• Use of prescription or nonprescription drugs and dietary and herbal supplements within 14 days or 7 half-lives;
• Positive screening tests for hepatitis B or C, HIV, alcohol, drugs of abuse.
• Previous administration with an investigational product (drug or vaccine) within 3 months;