A Study of SIM0689 in Adult Participants With Locally Advanced or Metastatic Solid Tumors

Inclusion criteria

• In dose-escalation cohorts (Part 1), histologically or cytologically documented advanced or metastatic solid tumor that is refractory/relapsed to standard therapies, or for which no effective standard therapy is available, or the subject refuses standard therapy.
• In the dose-expansion cohorts (Part 2), histologically or cytologically confirmed selected advanced solid tumors.
• Subjects must have at least one measurable lesion according to RECIST Version1.1.
• Eastern Cooperative Oncology Group (ECOG) Performance Score of 0 or 1.
• Adequate organ function.
• Available archived tumor tissue sample to allow for correlative biomarker studies. If unavailable or unsuitable, the subject must consent and undergo fresh tumor biopsy.
• Life expectancy ≥12 weeks.
• Patients of childbearing potential (male and female) must agree to use reliable methods of contraception until at least 180 days after the last dose.

Exclusion criteria

• Symptomatic brain metastases.
• Serious non-healing wounds, ulcers or fractures.
• Toxicity from previous treatment has to restore to ≤ grade 1.
• Major surgery (excluding biopsy) or significant trauma within 4 weeks prior to enrollment.
• Use of aspirin (> 325 mg/day) within 6 months prior to the first dose.
• Active hepatitis B or hepatitis C.
• Known human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS).
• Known hereditary or acquired predisposition to bleeding and thrombosis.
• History of gastrointestinal perforation, gastrointestinal bleeding, fistula, or any life-threatening bleeding event within 6 months prior to enrollment.
• Prior permanent discontinuation of PD-(L)1 and/or VEGF monoclonal antibody because of immune/anti-angiogenesis toxicities, or history of Grade ≥3 immune/anti-angiogenesis-related AEs
• Known or suspected active autoimmune disease.
• Patients with proteinuria at screening (Urine protein >2+ at screening, or 2+ urine protein accompanied by 24-h urine protein ≥1 g/24 h).
• History of myocardial infarction or stroke within 6 months prior to enrollment.
• Subjects with clinically significant cardiovascular disease within 6 months prior to the first dose.
• Pregnant and lactating women.
• Known allergies to any excipient in the study drug.