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NCT Number: NCT07178509

A Study of SCAD Using Stress Contrast Echocardiography

This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.

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Key information

Conditions

Spontaneous Coronary Artery Dissection Coronary Artery Dissection, Spontaneous

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic

Rochester, Minnesota, 55905, United States

Location status: Recruiting

Location contact

Marysia S Tweet, M.D., M.S.

PRINCIPAL_INVESTIGATOR

Pamela Engrav

CONTACT

[email protected]

507-255-6938

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult >18 years old
  • Patient has a history of spontaneous coronary artery dissection (SCAD) OR patient is healthy with no significant medical history

Exclusion criteria

  • Unable to give consent
  • Allergic or have a history of adverse reaction to dobutamine, the Definity® ultrasound enhancing agent, or atropine.
  • Has a known or suspected hypersensitivity to perflutren and therefore cannot be given Definity®.
  • Pregnant.
  • Unable to interrupt breastfeeding.
  • Within 3 months of a heart attack.
  • Severe aortic stenosis.
  • Severe, uncontrolled hypertension (>200/110 mmHg at baseline).

Treatment and study plan

Stress Echocardiography with Contrast

Procedure

Stress Echocardiography with Contrast will be used to assess heart function and blood flow response to stressors.

Primary outcomes

  1. Change in Microvascular Function

    Time frame: Baseline, immediately after the Stress Echocardiography

    Microvascular Function will be determined by Microvascular Blood Flow (Liters/Minute). Microvascular Blood Flow will be measured by a stress echocardiogram with contrast. A higher Microvascular Blood Flow indicated better blood flow circulation.

  2. Change in Blood Pressure

    Time frame: Baseline, immediately after the Stress Echocardiography

    Change is blood pressure will be measured by a stress echocardiogram with contrast (mmHg).

  3. Change in Heart Rate

    Time frame: Baseline, immediately after the Stress Echocardiography

    Change in heart rate will be measured by a stress echocardiogram with contrast (beats per minute).

Study contacts

Contact information is provided by the study sponsor or research team.

Pamela Engrav

CONTACT

[email protected]

507-255-6938

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

Registry information

Official study title

Myocardial Perfusion in Spontaneous Coronary Artery Dissection Using Stress Contrast Echocardiography

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Sep 17, 2025
Registry last updated
Jan 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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