A Study of Remimazolam Tosilate for Prolonged Sedation in the ICU

Inclusion criteria

• Patients or their guardians are able to provide a written informed consent
• Subjects have been treated with endotracheal intubation and mechanical ventilation, and is expected to receive sedation after randomization. The target level and duration of sedation meet the criteria
• Age ≥ 18 and ≤ 80 years, male or female
• Body mass index (BMI) > 18 and < 30 kg/m2

Exclusion criteria

• participants (other than in endotracheal intubation) who are expected to require neuro-muscle blockers during sedation；
• Suffering from mental disorders (such as schizophrenia, depression, etc.) and cognitive dysfunction;
• Organ failure during screening period；
• Subjects who were receiving dialysis during the screening period or who were expected to require dialysis treatment during the study period;
• History of epilepsy or status epilepticus;
• Subjects with a history of drug abuse；
• Myasthenia gravis or a history of myasthenia gravis;
• severe arrhythmias or heart disease;
• Subjects after neurosurgery operation；
• participants who did not require continuous sedation during mechanical ventilation for endotracheal intubation;
• Abnormal values of the laboratory examination
• Subjects who required vasopressor medication to maintain normotensive blood pressure during the screening period (excluding subjects who used vasopressor medication only during surgery);
• Allergic to relevant drugs ingredient or component;
• Pregnant or nursing women;
• Subjects who has participated in clinical trials of other interventions recently;
• Other conditions deemed unsuitable to be included.