A Study of Prevention and Treatment of Postmenopausal Osteoporosis in Chinese Women

Research purposes: To assess the Impact of hormone therapy on quality of life in early post-menopausal women; To assess the Impact of hormone therapy on cardiovascular system in early post-menopausal women; To assess the Impact of hormone therapy on cognitive function in early post-menopausal women; To assess the Impact of hormone therapy on osteoporosis in early post-menopausal women.

Study Design:

The clinical trial research was divided into 2 groups. Treatment group given estradiol valerate 1mg/d, periodic application of medroxyprogesterone 6mg/d for 10 days, calcium 900mg/d, VitD200iu/d and exercise(Brisk walking every day 2 times, continued for 10 minutes each time). Control group given placebo, calcium,VitD and exercise were same with treatment group.

Inclusion criteria

All patients meet the criteria:

• Patients with informed consent.
• Breast Cancer inform possible danger.
• Physical and mental health.

Menopausal transition meet the criteria:

• Age between 40 ~ 55 years old.
• Women with Menopause syndrome or menstrual disorders.
• The second to fourth lumbar spine bone mineral density to normal.

Early postmenopause meet the criteria:

• Age between 45 ~ 60 years old.
• Spontaneous amenorrhea for more than six months and less than 5 years.
• The second to fourth lumbar spine bone mineral density was between -1 and -2.5 Standard deviation Compared with normal young women.

Exclusion criteria

• Tobacco or alcohol abuser.
• History of various malignant diseases.
• Women with Serious chronic diseases, such as liver and kidney dysfunction.
• Women Suffering from endocrine diseases, such as Thyroid disease, Parathyroid disease,Adrenal disease and Osteomalacia.
• Women with Long-term application of drugs, such as Antiepileptic drug, Adrenocorticotropic hormone, Diuretics and Heparin.
• Women had used estrogen or calcitonin in the past 6 months.
• Women has added higher than the physiological requirements VitD.
• Who had taken bisphosphonates or sodium fluoride in the past 1 year.
• Women had been taking Chinese medicines or other unregistered food in past 3 months.
• Women with one of the following medical history or disease: Thrombophlebitis, estrogen-related thrombosis or thromboembolism, Cerebrovascular accident, with known or suspected estrogen-dependent tumor, undiagnosed vaginal bleeding, Cervical Pap smear graded at 3 or more, Serious uterine disorders, Serious breast disorders, Serious gallbladder disease, Severe hypertension and Hypercholesterolemia
• Secondary osteoporosis.
• Participants' lumbar spine anatomy(at least L1~L4) is not suitable to do dual-energy X-ray absorptiometry measured, such as obvious scoliosis, bone injury and Orthopedic surgery Sequelae.
• Doctor consider inappropriate to participate in because of other diseases.