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NCT Number: NCT05676008

A Study of Positive Emotions With Long COVID-19

This study is testing a new brief mindfulness practice for people suffering from long COVID-19 symptoms. People suffering from long COVID are particularly vulnerable to negative emotions, as they must also cope with the long-term uncertainty of physical and psychological stress beyond the acute infection. The goal of the study is to measure the ability of a brief mindfulness practice to promote a sense of well-being in people suffering from long COVID.

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This study is active but is not currently recruiting participants.

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Key information

About this study

This is a pilot randomized waitlist-controlled clinical trial (RCT) testing a new brief self-care intervention for people suffering from post-acute sequelae SARS-CoV-2 infection (PASC). The overarching goal of this study is to establish the feasibility and early efficacy of microdosing mindfulness as a self-care intervention. The purpose of the intervention is to promote a sense of well-being among PASC patients who currently have limited access to other proven self-care modalities.

Our research question is whether our newly developed training can assist PASC patients to self-microdose mindfulness (5-15 seconds activities in everyday life) and improve on perceived metrics of well-being (primary outcome). Our hypothesis is that self-microdosing mindfulness will evoke positive emotions that can improve well-being on patients suffering of PASC-related symptoms beyond 3 months post COVID-19 infection. If effective, an increased frequency of the mindfulness activity will then help buffer negative emotions (e.g., anger, loneliness, etc.) experienced during the pandemic and associated with ongoing stress and/or somatic symptoms.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Able to participate in online zoom sessions and complete online surveys for 3 months
  • English speakers
  • Had a mild to moderate in severity COVID-19 infection > 3 months ago, feeling unwell, and are still experiencing in the present at least one PASC-related symptoms:
  • Coughing or feeling short of breath
  • Loss of smell or change in taste
  • Recurrent Fever
  • Body aches, headaches, chest pain, or stomach pain
  • Brain fog (feeling like you can't think clearly)
  • Having trouble sleeping
  • Feeling very tired
  • Mood changes

Exclusion criteria

  • Adults that were admitted to an intensive care unit or placed on a respirator, had invasive heart (heart catheterization) or lung tests (bronchoscopy) performed.
  • Prisoners

Treatment and study plan

Microdosing of mindfulness

Behavioral

The intervention consists of two parts: 1) four structured training sessions offered as online synchronous classes, and 2) self-microdosing of mindfulness activities in everyday life.

Primary outcomes

  1. Well-being

    Time frame: 1 month

    14 items from the Mental Health Continuum Short Form

Secondary outcomes

  1. Perceived Stress

    Time frame: 1, 3 and 12 months

    Perceived Stress Scale

  2. Anxiety symptoms

    Time frame: 1, 3 and 12 months

    Generalized Anxiety Disorder scale

  3. Depressive symptoms

    Time frame: 1, 3 and 12 months

    Beck Depression Inventory Short Form

  4. Physical health

    Time frame: 1, 3 and 12 months

    Physical health symptoms - 11 items + 3 items of COVID symptoms

  5. Cardiac symptoms

    Time frame: 1, 3 and 12 months

    Cardiac symptoms by the Kansas City Cardiomyopathy Questionnaire-12 items (KCCQ-12)

  6. Well-being

    Time frame: 3 and 12 months

    14 items from the Mental Health Continuum Short Form

Sponsors and collaborators

Lead sponsor

University of California, Davis

Other

Registry information

Official study title

A Study of Positive Emotions With Long COVID (Post-Acute Sequelae of SARS CoV-2 Infection)

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
Jan 9, 2023
Registry last updated
May 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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