A Study of PM8002 Plus Nab-paclitaxel as First Line Therapy for TNBC

PD-L1 and VEGF play important roles in immune escape and tumor angiogenesis and enhance cancer growth and metastasis. PM8002 is a bispecific antibody targeting PD-L1 and VEGF-A. Here, the investigators present the results from a Phase Ib/II study of PM8002 in combination with nab-paclitaxel in subjects with locally advanced or metastatic triple negative breast cancer without previous systematic treatment.

Inclusion criteria

• Voluntarily participate in clinical research; fully understand the study and voluntarily sign the informed consent; willing to follow and have the ability to complete all trial procedures;
• Male or female, aged 18 to 75 years (including boundary value);
• Unresectable locally advanced or metastatic breast cancer confirmed by histology or cytology, ER, PR, HER-2 are all negative. Negative ER and PR were defined as: IHCER < 1%, IHCPR < 1%. HER-2 negative is defined as: IHCHER-2 (-) or (1+), HER-2 (2+) must be tested by FISH and the result is negative.
• Patients who have not received systemic treatment for advanced TNBC in the past are allowed to use taxane anti-tumor therapy in the previous neoadjuvant and/or adjuvant treatment stage, but must meet the end time of taxane neoadjuvant and/or adjuvant treatment Recurrence/metastasis interval ≥ 12 months;
• Sufficient organ function;
• The Eastern Cooperative Oncology Group (ECOG) score of physical status is 0-1;
• Expected survival period ≥ 12 weeks;
• According to the RECIST1.1 standard, the subject has at least one measurable tumor lesion.

Exclusion criteria

• History of severe allergic diseases, allergic history of serious drugs (including unlisted test drugs) or known allergic to any component of this test drug;
• Previously received any antibody or inhibitor therapy targeting PD-1/PD-L1 or VEGF;
• There is meningeal metastasis, uncontrollable or symptomatic central nervous system (CNS) metastasis;
• Those who have active infection and currently need intravenous anti-infection treatment;
• At present, there are uncontrollable pleural effusion, pericardium effusion and abdominal effusion;
• Before the start of the study and treatment, fever of unknown cause > 38.5°C (according to the researcher's judgment, fever caused by tumor can be included in the group);
• Known history of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation;
• Known history of alcohol abuse, psychotropic substance abuse or drug abuse;
• Have a clear history of neurological or mental disorders, such as epilepsy, dementia and schizophrenia;
• Human immunodeficiency virus (HIV) infection or known acquired immunodeficiency syndrome (AIDS);
• Syphilis nonspecific antibody test is positive (such as TRUST and PRP) or syphilis specific antibody test is positive (such as TPPA) [it is acceptable that "Syphilis specific antibody test" is positive but "Syphilis nonspecific antibody test" is negative for more than one year];
• Active tuberculosis, or a history of tuberculosis infection in the past but failed to control after treatment;
• Active hepatitis B (HBsAg positive and HBV-DNA ≥1 1000 IU/ml) can be controlled by antiviral drugs (HBV-DNA < 1000 IU/ml). Active hepatitis C (HCV-RNA > detection limit of research center);
• According to the researcher's judgment, the subject's basic illness may increase the risk of receiving the study drug, or confuse the explanation of the toxic reaction and AE;
• It is expected that any other form of anti-tumor drug treatment will be required during the study;
• Women who are pregnant or breastfeeding.