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Enrolling by Invitation

NCT Number: NCT05544721

A Study of Paravertebral Block in Thoracic Outlet Syndrome

This research is being done to evaluate the effects of receiving only a paravertebral block prior to first rib resection procedure versus receiving the block both pre and post procedure.

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Key information

Conditions

Thoracic Outlet Syndrome Cardiovascular Diseases Nerve Compression Syndromes Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Mayo Clinic in Florida

Jacksonville, Florida, 32224, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All Thoracic Outlet Syndrome patients scheduled for first rib resection surgery.

Exclusion criteria

  • Patients who are pregnant.
  • Patients with prior first rib resection on side of presentation.
  • Patients with complex regional pain syndrome (CRPS).
  • Patients with brachial plexus disorder.
  • Patients with cervical rib.

Treatment and study plan

Ropivacaine

Drug

0.5% 3-4 mL per level, with levels T1 and T2 will be used as the block injectate

Primary outcomes

  1. Change in pain level

    Time frame: Time of discharge (approximately 1 day), day 1 post-op, day 3 post-op, day 7 post-op, and day 14 post-op

    Measured using the pain visual analog scale (VAS). The VAS line will be 100 mm long with each end marked with "no pain" on the left, and "worst possible pain" on the right; participant identify their pain level by indicating a point on the line between each end and this point is measured from the "No pain" end, and the number of millimeters is reported as the pain score.

Secondary outcomes

  1. Change in quality of life

    Time frame: Time of discharge (approximately 1 day), day 1 post-op, day 3 post-op, day 7 post-op, and day 14 post-op

    Measured using the Short Form (SF-36) Health Survey; The SF-36 Health Survey is a 36-item, participant-reported survey that measures patient health and disability. Possible scores range from 0 to 100, with 0 indicating maximum disability, and 100 indicating no disability

  2. Length of stay

    Time frame: Approximately 1 day

    Number of hours subjects are in the hospital following their surgical procedure

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

Pre-Operative and Post-Operative Paravertebral Block on Patients With Thoracic Outlet Syndrome.

Important dates

Study start
2022
Primary completion
2027
Study completion
2027
First posted
Sep 16, 2022
Registry last updated
Nov 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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