A Study of Oral Minoxidil to Treat Hair Loss in Children, Teens, and Young Adults Who Are Cancer Survivors

Inclusion criteria

• Patients must have been diagnosed with cancer before the age of 17.
• They must have completed either systemic or radiation therapy (cytotoxic chemotherapy and external beam radiation therapy) for their cancer at least 1 year prior to study entry.
• They must be between 6-18 years old at the time of enrollment.
• They must have a clinical diagnosis of persistent or late alopecia for >6 months and that is definitely, probably, or possibly related to prior chemotherapy and/or radiation.

Exclusion criteria

• Had a history of alopecia prior to systemic or radiation therapy for cancer, or has alopecia unrelated to cancer treatment.
• Have scalp disorders that preclude the evaluation of alopecia, such as psoriasis
• Has a known hypersensitivity to minoxidil
• Concurrent use of other therapies for alopecia
• Concurrent active anticancer therapies (cytotoxic, targeted, endocrine, immunologic)
• History of chronic sclerotic cutaneous GvHD affecting the scalp
• Active chronic cutaneous GvHD
• History of orthostatic or symptomatic hypotension, syncope related to hypotension; systolic less than or equal than 100 (for adults) and 90 (for children) at screening.
• Pregnancy.
• Cardiovascular disease that in the opinion of the cardiologist makes the patient unsuitable for therapy
• Blood pressure less than the 5th percentile or less than 90/50 mmHg for children 10 years or older