A Study of Olomorasib (LY3537982) in Participants With Hepatic Impairment and Healthy Participants

Inclusion criteria

• Males and females of non-childbearing potential.
• Men or women with a body mass index of 18.0 to 40.0 kilograms per meter squared (kg/m²).
• Able to comply with all study procedures, including the 5- to 6-night stays at the CRU and the follow-up phone call.
• Healthy participants: In good health, determined by no clinically significant findings from medical history, physical examination, 12-lead ECG, vital sign measurements, or clinical laboratory evaluations at screening and/or admission as assessed by the investigator (or designee).
• Participants with hepatic impairment: Diagnosis of cirrhosis due to parenchymal liver disease, which is confirmed and documented by at least one of the following: medical history, physical examination, hepatic ultrasound, computed axial tomography scan, magnetic resonance imaging, and/or liver biopsy.

Exclusion criteria

• Females who are lactating or of childbearing potential.
• History or presence of any of the following, deemed clinically significant by the Investigator (or designee), and/or Sponsor:

• Metabolic disease
• Gastrointestinal disease
• Hematological disease
• Neurological disease
• History or presence of clinically significant cardiovascular disease.
• Abnormal laboratory values determined to be clinically significant by the Investigator (or designee).
• Clinically significant abnormality, as determined by the Investigator (or designee), from physical examination.
• Participation in any other investigational study drug trial involving administration of any investigational drug in the past 30 days or 5 half-lives, whichever was longer, prior to the first dose administration (Day 1).
• Use or intention to use any prescription or over-the-counter medications within 14 days prior to the first dose administration (Day 1) and through end of trial, unless deemed acceptable by the investigator (or designee) and medical monitor.
• History or presence, upon clinical evaluation, of any illness that, in the opinion of the Investigator, would interfere with the ability to provide informed consent or comply with study instructions, or that might confound the interpretation of the study results, or put the participant at undue risk.