A Study of Mezigdomide in Healthy Participants and Participants With Hepatic Impairment

Inclusion criteria

Hepatic Impaired Participants:

• Participants have mild, moderate, or severe hepatic impairment or cirrhosis due to chronic hepatic disease and/or prior alcohol use.
• Participants have mild (Group A), moderate (Group B), or severe (Group C) hepatic impairment as defined by Child-Pugh Score.

Matched Healthy Participants:

• Participant must be free of any clinically significant disease that would interfere with the study evaluations.
• Participant must have liver-related laboratory test results within the respective reference ranges or with clinically insignificant excursions therefrom as agreed by the investigator.

Exclusion criteria

All Participants:

• History of chronic pruritus or dermatologic syndromes that may be confounded with reactions to mezigdomide.
• Contraindication or intolerance to first-generation antihistamine medications.

Hepatic Impaired Participants:

-Clinical laboratory test results:

• Platelet count lower than 30,000/microliter (μL) at screening or Day -1.
• Absolute neutrophil counts lower than 1,500/μL at screening or Day -1.

Matched Healthy Participants:

-History of or suspected benign ethnic neutropenia.

Other protocol-defined inclusion/exclusion criteria apply