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NCT Number: NCT07225309

A Study of Meaning-Centered Therapy for Mexican Adults With Advanced Cancer

The purpose of this study is to find out if Meaning-Centered Psychotherapy for Latinos (MCP-L) helps reduce anxiety and depression and improves quality of life compared to cognitive behavioral therapy (CBT). Investigators also want to learn what participants and providers think about the therapy, including how the therapy is designed, outside factors, available resources, and how the people involved affect how well MCP-L works.

Recruiting

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Key information

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Patient Eligibility Criteria:

A patient cannot be considered eligible for this study unless ALL of the following conditions are met. Participant eligibility will be determined by an initial EMR review followed by a self-report screener and suicide risk assessment.

Inclusion criteria

EMR Criteria

  • Documentation of Disease
  • Pathologically confirmed breast, prostate, colorectal, thyroid, cervix, uteri, or lung - solid tumor cancer (either most recent or new diagnosis)
  • Definition of Disease [or Measurable Disease]
  • Diagnosed with stages III or IV
  • Prior Treatment
  • Receiving ambulatory care at INCan

Self-Report Criteria

  • Age ≥ 18 years
  • Able to read and communicate in Spanish determined by the question: "Can you read and communicate in Spanish? Yes/No"
  • Professional role of administrators, clinicians (e.g., oncologists), mental health providers, supervised therapists-in-training (e.g., graduate students), or other related provider delivering the MCP-L experimental intervention
  • Providing care (or services) to Mexican cancer patients at INCan
  • Has access to internet and an electronic device
  • Agrees to be audio-recorded

Exclusion criteria

EMR Criteria

  • Prior Treatment
  • Received psychological or psychiatric care at INCan in the last 3 months
  • In the judgment of the treating physician, protocol investigators, and/or study staff, presence of cognitive impairment (e.g., delirium or dementia) sufficient to preclude meaningful informed consent and/or study participation
  • Diagnosed with a serious psychiatric condition

Self-Report Criteria

  • Received psychological or psychiatric care outside of INCan in the last 3 months
  • Presence of suicide risk determined by the Columbia-Suicide Severity Rating Scale
  • Too ill to participate determined by the question: "Do you feel too ill to participate because of communication problems, uncontrollable pain, or other symptoms that prevent you from participating?"

Provider Eligibility Criteria:

Inclusion criteria

Self-Report Criteria

  • Age ≥ 18 years
  • Able to read and communicate in Spanish determined by the question: "Can you read and communicate in Spanish? Yes/No"
  • Professional role of administrators, clinicians (e.g., oncologists), mental health providers, supervised therapists-in-training (e.g., graduate students), or other related provider delivering the MCP-L experimental intervention
  • Providing care (or services) to Mexican cancer patients at INCan
  • Has access to internet and an electronic device
  • Agrees to be audio-recorded

Treatment and study plan

Meaning-Centered Psychotherapy for Latinos /MCP-L

Behavioral

MCP-L is a structured 7-session manualized intervention culturally adapted into Spanish for Latino participants diagnosed with advanced cancer, which utilizes a mixture of didactics, discussion and experiential exercises that focus on particular themes related to meaning and advanced cancer. It is 60-minute individual sessions delivered every week or intermittently (depending on participant preference) for up to approximately 3 months (in this time period) in the event of medical illness.

Primary outcomes

  1. Change in clinical levels of anxiety and depression for participants participating in Meaning-Centered Psychotherapy for Latinos (MCP-L)

    Time frame: 1 month

    To examine the efficacy of Meaning-Centered Psychotherapy for Latinos (MCP-L) in improving clinical levels of anxiety and depression at 1-month post-intervention follow-up. Assessed using the General Anxiety Disorder 7-item scale (GAD-7; range 0-21, higher scores indicate greater anxiety levels) and the Patient Health Questionnaire 9-item scale (PHQ-9; range 0-27, higher scores indicate greater depression levels), respectively.

  2. Change in clinical levels of anxiety and depression for participants participating in Meaning-Centered Psychotherapy for Latinos (MCP-L)

    Time frame: 3 months

    To examine the efficacy of Meaning-Centered Psychotherapy for Latinos (MCP-L) in improving clinical levels of anxiety and depression at 3-month post-intervention follow-up. Assessed using the General Anxiety Disorder 7-item scale (GAD-7; range 0-21, higher scores indicate greater anxiety levels) and the Patient Health Questionnaire 9-item scale (PHQ-9; range 0-27, higher scores indicate greater depression levels), respectively.

Study contacts

Contact information is provided by the study sponsor or research team.

Francesca Gany, MD, MS

CONTACT

[email protected]

646-888-8054

Rosario Costas Muniz, PhD

CONTACT

[email protected]

646-888-8062

Sponsors and collaborators

Lead sponsor

Memorial Sloan Kettering Cancer Center

Other

Registry information

Official study title

Trial of Meaning Centered Psychotherapy for Mexican Patients With Advanced Cancer

Important dates

Study start
2026
Primary completion
2029
Study completion
2029
First posted
Nov 6, 2025
Registry last updated
Jun 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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