A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

Inclusion criteria

• Have type 2 diabetes
• Have an HbA1c ≥7.5% to ≤10.5% at screening
• Have been treated with any of the following, alone or in combination, for at least 3 months prior to screening

• Diet and exercise
• Stable dose of metformin
• Sodium-glucose cotransporter-2 (SGLT2) inhibitor
• Have had a stable body weight (<5% body weight gain and/or loss) for the 3 months prior to screening
• Have a BMI of 27 or greater at screening

Exclusion criteria

• Have any form of diabetes other than type 2 diabetes
• Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed >1 year prior to screening
• Have any of the following cardiovascular conditions within 3 months prior to screening:

• acute myocardial infarction
• cerebrovascular accident (stroke)
• unstable angina, or
• hospitalization due to congestive heart failure
• Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years, exceptions include

• basal or squamous cell skin cancer
• in situ carcinomas of the cervix, or
• in situ prostate cancer
• Have been prescribed any of the following receptor agonists (RA) or their combination for any indication within the last 6 months:

• amylin RA
• dual amylin and calcitonin RA
• glucagon-like peptide-1 receptor (GLP-1) RA
• glucose-dependent insulinotropic peptide (GIP)/GLP-1 RA
• GLP-1/glucagon (GCG) RAs, or
• GIP/GLP-1/GCG RAs
• Have used excluded antihyperglycemic medications within 3 months prior to screening (including, but not limited to, sulfonylureas, dipeptidyl peptidase-4 inhibitors, alpha-glucosidase inhibitors, thiazolidinediones, and meglitinides
• Have used insulin for diabetic control within the prior year (short term use in certain situations allowed