A Study of LY4100511 (DC-853) Mass Balance and Absolute Bioavailability of LY4100511 in Healthy Male Participants

Inclusion criteria

• Body mass index between 18.0 and 32.0 kilogram per square meter (kg/m2), inclusive, and a body weight of ≥50 kilogram (kg)
• In good health and determined by no clinically significant finding from medical history, 12-lead ECG and vital signs measurements, and clinical laboratory evaluations (congenital nonhemolytic hyperbilirubinemia, e.g., suspicion of Gilbert's syndrome based on total and direct bilirubin is not acceptable) at screening and check-in, and from the physical examination at check-in, as assessed by the Investigator or designee
• History of a minimum of 1 bowel movement per day.
• Able to provide a fecal sample between check-in on Day-2 and oral dosing on Day 1.

Exclusion criteria

• Have a 12-lead ECG abnormality that, in the opinion of the Investigator

• increases the risks associated with participating in the study
• may confound ECG data analysis
• a QTcF & > 450 msec
• short PR interval & <120 msec or PR interval >220 msec
• second- or third-degree atrioventricular block
• intraventricular conduction delay with QRS 120 msec
• right bundle branch block
• left bundle branch block, or
• Wolff Parkinson-White syndrome.
• Have a current or recent acute, active infection (for example, for at least 30 days before screening and up to check-in, participants must have no symptoms or signs of infection in the absence of any anti-infective treatment).
• Had any malignancy within the past 5 years. Exceptions: successfully treated basal cell skin carcinoma or squamous cell skin carcinoma, with no evidence of recurrence or metastatic disease within the 3 years prior to baseline.
• Are immunocompromised.
• Have inflammatory bowel disease (IBD)