A Study of LY3015014 in Participants With High Cholesterol

Inclusion criteria

• Diagnosed with high low density lipoprotein (LDL) cholesterol
• Are on stable daily dose of a statin or have a history of statin intolerance
• Men with a partner who can become pregnant must agree to use barrier protection during sexual intercourse to prevent pregnancies
• Women who cannot become pregnant, or women who are not pregnant or breast feeding and agree to use a reliable method of birth control to prevent pregnancies

Exclusion criteria

• Have high cholesterol due to another disease or have a rare and serious form of hereditary high cholesterol
• Have had recent heart attack, stroke, blood clot or heart surgery, have planned heart or blood vessel surgery, or has a heart that does not pump sufficiently well
• Have poorly controlled high blood pressure
• Have diabetes that requires an injectable medication (including insulin), or have diabetes that is poorly controlled
• Have thyroid blood test that is outside normal range
• Have a history of adrenal gland disorder
• Have a history of vitamin E deficiency or fat malabsorption syndrome
• Have poor kidney function
• Have active liver or gall bladder disease, history of hepatitis or liver blood tests that are high
• Have a history of muscle disease including muscle damage from a medicine or muscle blood test that is high
• Are anemic (low red blood cell counts)
• Have a history of allergy or intolerance to other antibody medications
• Have a history of human immunodeficiency virus infection (HIV) infection
• Are likely to have a major operation or be hospitalized during the study
• Have chronic alcohol or drug abuse or dependency
• Have or suspected to have any cancer or malignant tumor
• Have an active serious infection
• Have started or stopped taking a statin or ezetimibe medication, or changed statin dose regimen recently
• Are on a statin regimen other than daily dosing (for example, an every-other-day statin regimen)
• Have recently used simvastatin (highest dose level), fibrates, bile acid binders, niacin, probucol, or over-the-counter/health food preparations to lower cholesterol (such as red yeast rice, fish oil, omega 3 fatty acid)
• Have undergone LDL apheresis in the past 1 year
• Have recently used steroids, cyclosporine or isotretinoin
• Have recently used an immunosuppressive therapy
• Have recently received treatment with another antibody medication
• Are currently using medications injected into the skin , except for single injections (for example flu vaccines) or injections into muscles
• Are currently on a prescription or over-the-counter medicine for weight loss or are on a very low carbohydrate diet