A Study of LY2605541 (Insulin Peglispro) and Human Insulin Concentrations in Fat Tissue

Inclusion criteria

• Have a diagnosis of Type 1 Diabetes Mellitus (T1DM) based on medical history for at least 1 year prior to enrollment
• Have a c-peptide value ≤0.3 nanomoles per liter (nmol/L) at screening
• Have a serum creatinine value within normal limits at screening
• Have a haemoglobin A1c (HbA1c) value ≤75 millimoles per mole (mmol/mol) (9.0%) at screening
• Have a body mass index (BMI) of 20.0-30.0 kilograms per meter squared (kg/m^2), inclusive, at screening

Exclusion criteria

• Have known or suspected allergies or hypersensitivities to LY2605541, human insulin, sinistrin, related compounds or any components of the formulations
• Are women who are pregnant or lactating
• Have an abnormal blood pressure for the population as determined by the investigator
• Have renal insufficiency or major renal disorders
• Have proliferative retinopathy or maculopathy
• Have lipodystrophy
• Have any wound healing disorder or are prone to keloid or hypertrophic scar formation
• Have results of screening prothrombin time (PT) and international normalized ratio (INR) tests that are significantly prolonged
• Have a fasting triglycerides value > 4.52 millimoles per liter (mmol/L) (400 milligrams/deciliter (mg/dL))
• Are receiving chronic systemic or inhaled glucocorticoid or have received such therapy within the 4 weeks before dosing
• Have a total daily insulin dose greater than 1.2 units per kilogram (U/kg)
• Regular use or intended use of any over-the-counter or prescription medications or nutritional supplements that affect blood glucose or the body's sensitivity to insulin or that promote weight loss within 14 days prior to dosing
• Regular use or intended use of non-selective beta blockers
• Regular use or intended use of monoamine oxidase (MAO) inhibitors
• Are currently participating in a weight loss program or plan to do so during the course of the study
• Are unwilling to avoid excessive sun exposure, steam baths, saunas, and swimming during the study. Sun cream should be used during sun bathing for the 6-month period following the study
• Are unwilling to avoid extensive consumption of food containing inulin during the study and in the 48-hour period leading up to the clamp