A Study of HS-20094 in T2DM Participants

Inclusion criteria

• Male or female subjects,20-65 years of age at the time of signing informed consent.
• Type 2 diabetes mellitus diagnosed for at least 3 months before the screening visit.
• Treated with conventional lifestyle intervention and stable treatment with metformin ( ≥ 1000 mg/day) at least 3 months prior to screening HbA1c 7.5-10%(both inclusive)at screening visit.

Exclusion criteria

• A history of type 1 diabetes, specific diabetes, or secondary diabetes.
• Presence of-clinically significant lab or ECG results that may affect the evaluation of the efficacy or safety of the study drug at screening visit.
• Acute or chronic pancreatitis at any time before screening, or serum lipase/amylase above the upper limit of normal at screening.
• A history of grade 2 hypoglycemia(blood glucose 3.0 mmol/L)or grade 3 hypoglycemia(hypoglycemia with a serious event of consciousness and/or physical alteration requiring assistance from another person for recovery)within 6 months before screening.
• Diabetid ketoacidosis or hyperosmolar coma or lactic acidosis requiring hospitalization occurred within 6 months before screening.
• Severe infection such as diabetic foot infection, pneumonia, or sepsis within 30 days before screening.
• Uncontrollable hypertension.
• History of acute cardiovascular and cerebrovascular diseases within 6 months prior to screening.
• Any organ-system malignancies developed within 5 years except for cured local basal cell carcinoma of the skin and carcinoma in situ of the cervix.
• Pregnant or lactating woman.
• In the investigator's judgment, there were circumstances that affected subject safety or otherwise interfered with the evaluation of results.