Mayo Clinic
Rochester, Minnesota, 55905, United States
Location status: Recruiting
Recruiting
NCT Number: NCT07137286
A Study of Genetic Influence on LDL Hyper-responsiveness in Patients Following a Ketogenic Diet
The purpose of this study is to identify whether individuals following a ketogenic diet who experience extreme LDL-C elevation, termed "hyper-responders", have identifiable genetic variations in genes involved in cholesterol absorption.
Recruiting
Interested in participating?
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Conditions
Age range
18 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- 18 years of age or older
- LDL-C >170 mg/dL in response to starting a ketogenic diet
Exclusion criteria
- Patients who do not consent to blood draw for genetic testing
- Those with LDL-C <170 mg/dL on a ketogenic diet
Treatment and study plan
Primary outcomes
-
Number of Patients to have a genetic mutation
Time frame: Baseline
Genetic Mutation will be defined as a mutation in ABCG5, ABCG8, APOB, APOE, CETP, CYP27A1, LDLR, LDLRAP1, LIPA, LPL, LRP6, and PCSK9 genes
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Mayo Clinic
Other
Registry information
Official study title
Genetic Influence on LDL Hyper-responsiveness in Patients Following a Ketogenic Diet
Important dates
- Study start
- 2025
- Primary completion
- 2027
- Study completion
- 2027
- First posted
- Aug 22, 2025
- Registry last updated
- Nov 20, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.