A Study of EDG-15400 in Healthy Adults

Inclusion criteria

• Willing and able to give informed consent and follow all study procedures and requirements.
• Healthy male or nonpregnant female, ages ≥18 to <60 years.
• Body mass index (BMI) ≥18.5 to <35 kg/m2; weight ≥55 kg at Screening.
• Absence of important health problems and essentially normal physical examination, normal laboratory screening tests, and normal electrocardiogram (ECG) with QTc interval corrected for heart rate using the Fridericia method (QTcF) ≤450 ms.

Exclusion criteria

• Evidence of clinically significant abnormalities or disease.
• Unless permitted by protocol, use of any prescription medication ≤ 4 weeks or investigational medication ≤ 12 weeks or ≤ 5 half-lives (whichever is longer) of dosing. Use of any non-prescription medication or herbal/nutritional supplement ≤ 5 days prior to dosing.
• Donation or loss of > 1 unit (450 mL) of blood ≤ 1 month prior to dosing.
• Females: nursing, lactating, or pregnant.
• Females: breast implants.
• Use of nicotine-containing products in the last 6 months prior to dosing.
• History of substance abuse or dependency or history of recreational drug use within the last 2 years.
• Alcohol consumption > 14 drinks per week for males (7 for females) within 45 days of screening.
• Positive screen for drugs of abuse or alcohol or nicotine exposure test at Screening or Admission.

Additional protocol defined inclusion/exclusion criteria may apply.