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NCT Number: NCT07093528

A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD

To evaluate the effect of CS reducer implantation in patients with HFPEF and CMD on myocardial ischemia, measured by stress myocardial perfusion using cardiovascular magnetic resonance (CMR)

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Key information

Conditions

Heart Failure With Preserved Ejection Fraction Coronary Microvascular Dysfunction

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic

Rochester, Minnesota, 55905, United States

Location status: Recruiting

Location contact

Claire Raphael, M.B.B.S., Ph.D.

PRINCIPAL_INVESTIGATOR

Diana Albers

CONTACT

[email protected]

507-255-6884

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥18
Enrollment in main CS-reducer HFPEF study IRB# 25-002292

Exclusion criteria

Metal implants that are not suitable for MRI
Inability or unwillingness of individual to give written informed consent.

Treatment and study plan

cardiovascular magnetic resonance (CMR)

Diagnostic Test

Patients will consent to undergo a 50-minute non-invasive stress perfusion CMR.

Primary outcomes

Change in endocardial:epicardial perfusion ratio

Time frame: Baseline, 6 Months

Endocardial:Epicardial Perfusion Ratio is a measure of myocardial blood flow and will be determined by Cardiovascular magnetic resonance (CMR)

Study contacts

Contact information is provided by the study sponsor or research team.

Diana Albers

CONTACT

[email protected]

507-255-6884

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

CMR Substudy of Coronary Sinus Reducer for the Management of Symptomatic Heart Failure With a Preserved Ejection Fraction (HFpEF) Associated With Coronary Microvascular Dysfunction (CMD)

Important dates

Study start: 2025
Primary completion: 2027
Study completion: 2027
First posted: Jul 30, 2025
Registry last updated: Feb 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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