Recruiting

NCT Number: NCT05954832

A Study of Changes in Heart Function and Blood Flow in People Receiving Anesthesia

The purpose of this study is to understand changes in heart function (how the heart pumps blood) and blood flow in people who receive general anesthesia during surgery. The researchers are particularly interested in the heart function and blood flow changes in people who experience low blood pressure (hypotension) after receiving anesthesia.

Recruiting

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Key information

Conditions

Anesthesia

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Memorial Sloan Kettering Cancer Center (All protocol activites)

New York, 10065, United States

Location status: Recruiting

Location contact

Anahita Dabo-Trubelja, MD

CONTACT

212-639-3279

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult patients ≥ 18 years of age requiring general anesthesia for surgery
Intubation required for anesthetic management / surgery
Anticipated prep time before incision of 20 minutes
Baseline MAP >70mmHg

Exclusion criteria

History of coronary artery disease
History of cardiac disease (e.g., HTN, arrythmias, valvular and structural abnormalities)
History of peripheral artery occlusive disease
Beta-blocker use
Anti-hypertensive medication use
Patients with epidural, spinal, paravertebral, serratus blocks preoperatively
Patients requiring rapid sequence induction (where intubation occurs concurrently with induction)
Emergency surgery

Treatment and study plan

Echocardiography

Diagnostic Test

Echocardiography and Clearsight BP measurements before, immediately after anesthesia induction and after intubation (for 20 min)

Primary outcomes

The proportion of patients with post-induction hypotension (PIH)

Time frame: up to 20-mins after anesthesia induction.

summarize the distributions of the echocardiography parameter values (pre-load LVEDd(cm), after-load LVEDs(cm), other measures [e.g., contractility (EF %) and structural abnormalities]) across each timepoint among patients with and without PIH

Study contacts

Contact information is provided by the study sponsor or research team.

Anahita Dabo-Trubelja, MD

CONTACT

[email protected]

212-639-3279

Gregory Fischer, MD

CONTACT

212-639-2581

Sponsors and collaborators

Lead sponsor

Memorial Sloan Kettering Cancer Center

Other

Registry information

Official study title

Changes in Loading Conditions on Induction of General Anesthesia: Mechanisms of Post-Induction Hypotension (PIH)

Important dates

Study start: 2023
Primary completion: 2027
Study completion: 2027
First posted: Jul 20, 2023
Registry last updated: Jan 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Recruiting